Lipid hijacking: a unifying theme in vector-borne diseases

AJ O'Neal, LR Butler, A Rolandelli, SD Gilk, JHF Pedra - Elife, 2020 - elifesciences.org
Vector-borne illnesses comprise a significant portion of human maladies, representing 17%
of global infections. Transmission of vector-borne pathogens to mammals primarily occurs …

Plasmodium development in Anopheles: a tale of shared resources

WR Shaw, P Marcenac, F Catteruccia - Trends in Parasitology, 2022 - cell.com
Interactions between the Anopheles mosquito vector and Plasmodium parasites shape how
malaria is transmitted in endemic regions. The long association of these two organisms has …

Wolbachia cifB induces cytoplasmic incompatibility in the malaria mosquito vector

KL Adams, DG Abernathy, BC Willett, EK Selland… - Nature …, 2021 - nature.com
Wolbachia, a maternally inherited intracellular bacterial species, can manipulate host insect
reproduction by cytoplasmic incompatibility (CI), which results in embryo lethality in crosses …

A confinable female-lethal population suppression system in the malaria vector, Anopheles gambiae

AL Smidler, JJ Pai, RA Apte, HM Sánchez C… - Science …, 2023 - science.org
Malaria is among the world's deadliest diseases, predominantly affecting Sub-Saharan
Africa and killing over half a million people annually. Controlling the principal vector, the …

Multiple blood feeding in mosquitoes shortens the Plasmodium falciparum incubation period and increases malaria transmission potential

WR Shaw, IE Holmdahl, MA Itoe, K Werling… - PLoS …, 2020 - journals.plos.org
Many mosquito species, including the major malaria vector Anopheles gambiae, naturally
undergo multiple reproductive cycles of blood feeding, egg development and egg laying in …

Eliminating malaria vectors with precision-guided sterile males

RA Apte, AL Smidler, JJ Pai, ML Chow, S Chen… - Proceedings of the …, 2024 - pnas.org
Controlling the principal African malaria vector, the mosquito Anopheles gambiae, is
considered essential to curtail malaria transmission. However, existing vector control …

Mosquito heat seeking is driven by an ancestral cooling receptor

C Greppi, WJ Laursen, G Budelli, EC Chang… - Science, 2020 - science.org
Mosquitoes transmit pathogens that kill> 700,000 people annually. These insects use body
heat to locate and feed on warm-blooded hosts, but the molecular basis of such behavior is …

Fruitless mutant male mosquitoes gain attraction to human odor

NS Basrur, ME De Obaldia, T Morita, M Herre… - Elife, 2020 - elifesciences.org
The Aedes aegypti mosquito shows extreme sexual dimorphism in feeding. Only females
are attracted to and obtain a blood-meal from humans, which they use to stimulate egg …

The male mosquito contribution towards malaria transmission: Mating influences the Anopheles female midgut transcriptome and increases female susceptibility to …

FA Dahalan, TS Churcher, N Windbichler… - PLoS …, 2019 - journals.plos.org
Mating causes dramatic changes in female physiology, behaviour, and immunity in many
insects, inducing oogenesis, oviposition, and refractoriness to further mating. Females from …

Plasmodium oocysts respond with dormancy to crowding and nutritional stress

T Habtewold, AA Sharma, CAS Wyer, EKG Masters… - Scientific reports, 2021 - nature.com
Malaria parasites develop as oocysts in the mosquito for several days before they are able
to infect a human host. During this time, mosquitoes take bloodmeals to replenish their …