Cancer immunotherapy by immune checkpoint blockade has proven its great potential by
saving the lives of a proportion of late stage patients with immunogenic tumor types …

Glioblastoma (GBM) is the most aggressive, malignant primary brain tumor in adults. GBM is
notoriously resistant to immunotherapy mainly due to its unique immune microenvironment …

The dynamics and phenotypes of intratumoral myeloid cells during tumor progression are
poorly understood. Here we define myeloid cellular states in gliomas by longitudinal single …

Immunotherapy based on immunecheckpoint blockade (ICB) using antibodies induces
rejection of tumours and brings clinical benefit in patients with various cancer types …

The Glioblastoma (GBM) immune microenvironment plays a critical role in tumor
development, progression, and prognosis. A comprehensive understanding of the intricate …

Simple Summary Macrophages are a specialized immune cell type found in both
invertebrates and vertebrates. Versatile in functionality, macrophages carry out important …

Despite significant strides made in understanding the pathophysiology of high-grade
gliomas over the past two decades, most patients succumb to these neoplasias within two …

Brain cancers carry bleak prognoses, with therapeutic advances helping only a minority of
patients over the past decade. The brain tumour microenvironment (TME) is highly …

Simple Summary This paper summarizes the crosstalk between tumor/non-tumor cells and
other elements of the glioblastoma (GB) microenvironment. In tumor pathology, glial cells …

The innate immune pathway is receiving increasing attention in cancer therapy. This
pathway is ubiquitous across various cell types, not only in innate immune cells but also in …