Members of the B cell lymphoma 2 (BCL-2) gene family have a central role in regulating
programmed cell death by controlling pro-apoptotic and anti-apoptotic intracellular signals …

The 70-kDa heat shock proteins (HSP70s) are abundantly present in cancer, providing
malignant cells selective advantage by suppressing multiple apoptotic pathways, regulating …

Atropisomerism is a dynamic type of axial chirality that is ubiquitous in medicinal chemistry.
There are several examples of stable atropisomeric US FDA-approved drugs and …

Venetoclax is a first-in-class cancer therapy that interacts with the cellular apoptotic
machinery promoting apoptosis. Treatment of patients suffering chronic lymphocytic …

Apoptosis is one of the major mechanisms exhibited in response to cell death and induction
of apoptosis in tumour cells signifies a potential target for cancer therapy. Bcl-2 family …

Cancer is amongst the deadliest and most disruptive disorders, having a much higher death
rate than other diseases worldwide. Human cancer rates continue to rise, thereby posing the …

Highlights•Selective BH3 mimetics for interrogating the BCL-2 protein family interactions and
their development for cancer therapy.•Non-canonical interactions of anti-apoptotic BCL-2 …

Escape from apoptosis is one of the major hallmarks of cancer cells. The B-cell Lymphoma 2
(BCL-2) gene family encodes pro-apoptotic and anti-apoptotic proteins that are key …

Protein–protein interactions (PPIs) control many important physiological processes within
human cells. Apoptosis or programmed cell death is closely regulated by pro-and …

There are current attempts to find a safe substitute or adjuvant for Sorafenib (Sorf), the
standard treatment for advanced hepatocellular carcinoma (HCC), as it triggers very harsh …