Chemotherapy, radiation therapy, as well as targeted anticancer agents can induce clinically
relevant tumor-targeting immune responses, which critically rely on the antigenicity of …

Small-molecule drug discovery has traditionally focused on occupancy of a binding site that
directly affects protein function, and this approach typically precludes targeting proteins that …

Autophagy is an essential cellular process affecting virus infections and other diseases and
Beclin1 (BECN1) is one of its key regulators. Here, we identified S-phase kinase-associated …

Rapid, efficient generation of knock-in mice with targeted large insertions remains a major
hurdle in mouse genetics. Here, we describe two-cell homologous recombination (2C-HR) …

Established tumors are typified by an immunosuppresive microenvironment. Countering this
naturally occurring phenomenon, emerging evidence suggests that radiation promotes a …

Conspectus Fluorescent nanodiamond (FND) has recently played a central role in fueling
new discoveries in interdisciplinary fields spanning biology, chemistry, physics, and …

We have designed a modular protein tagging system that allows different functionalities to
be linked onto a single genetic fusion, either in solution, in living cells, or in chemically fixed …

Protein fusion tags are indispensible tools used to improve recombinant protein expression
yields, enable protein purification, and accelerate the characterization of protein structure …

One major challenge in nanomedicine is the selective delivery of nanoparticles to diseased
tissues. Nanoparticle delivery systems require targeting for specific delivery to pathogenic …

Exploration of protein function and interaction is critical for discovering links among
genomics, proteomics, and disease state; yet, the immense complexity of proteomics found …