Next-generation, personalised, model-based critical care medicine: a state-of-the art review of in silico virtual patient models, methods, and cohorts, and how to …

JG Chase, JC Preiser, JL Dickson, A Pironet… - Biomedical engineering …, 2018 - Springer
Critical care, like many healthcare areas, is under a dual assault from significantly
increasing demographic and economic pressures. Intensive care unit (ICU) patients are …

Toward nutrition improving outcome of critically ill patients: How to interpret recent feeding RCTs?

J Gunst, MP Casaer, JC Preiser, J Reignier… - Critical Care, 2023 - Springer
Although numerous observational studies associated underfeeding with poor outcome,
recent randomized controlled trials (RCTs) have shown that early full nutritional support …

Higher glycemic variability within the first day of ICU admission is associated with increased 30-day mortality in ICU patients with sepsis

WC Chao, CH Tseng, CL Wu, SJ Shih, CY Yi… - Annals of intensive …, 2020 - Springer
Background High glycemic variability (GV) is common in critically ill patients; however, the
prevalence and mortality association with early GV in patients with sepsis remains unclear …

Digital twins and automation of care in the intensive care unit

J Geoffrey Chase, C Zhou, JL Knopp… - Cyber–Physical …, 2023 - Wiley Online Library
Healthcare is under increasing demand pressure as societies age and expectations rise,
multiplied by increasing incidence of chronic diseases and decreasing available funding …

Glycemic control in the intensive care unit: a control systems perspective

JG Chase, B Benyo, T Desaive - Annual Reviews in Control, 2019 - Elsevier
Computers and automation have revolutionised quality and productivity in many industries,
but not in medicine. Healthcare costs are thus growing beyond the ability of society to pay for …

Improving glycemic control in critically ill patients: personalized care to mimic the endocrine pancreas

JG Chase, T Desaive, J Bohe, M Cnop, C De Block… - Critical Care, 2018 - Springer
There is considerable physiological and clinical evidence of harm and increased risk of
death associated with dysglycemia in critical care. However, glycemic control (GC) currently …

Association between dysglycemia and mortality by diabetes status and risk factors of dysglycemia in critically ill patients: a retrospective study

H Ma, G Yu, Z Wang, P Zhou, W Lv - Acta Diabetologica, 2022 - Springer
Aims Dysglycemia, including the three domains hyperglycemia, hypoglycemia, and
increased glycemic variability (GV), is associated with high mortality among critically ill …

Effect of glycemic gap upon mortality in critically ill patients with diabetes

R Lou, L Jiang, B Zhu - Journal of Diabetes Investigation, 2021 - Wiley Online Library
Abstract Aims/Introduction Hyperglycemia, hypoglycemia, and blood glucose fluctuation are
associated with the outcome in critically ill patients, but the target of blood glucose control is …

Incorporating real-world evidence into the development of patient blood glucose prediction algorithms for the ICU

O Fitzgerald, O Perez-Concha, B Gallego… - Journal of the …, 2021 - academic.oup.com
Objective Glycemic control is an important component of critical care. We present a data-
driven method for predicting intensive care unit (ICU) patient response to glycemic control …

Glycemic control with insulin attenuates sepsis-associated encephalopathy by inhibiting glial activation via the suppression of the nuclear factor kappa B and mitogen …

CT Huang, JH Lue, TH Cheng, YJ Tsai - Brain Research, 2020 - Elsevier
Sepsis-associated encephalopathy (SAE) is frequently encountered in critically ill patients.
Hyperglycemia is a common phenomenon among patients with sepsis, and glycemic control …