Osteoporosis is the most common bone disease, affecting millions of people worldwide and
leading to significant morbidity and high expenditure. Most of the current therapies available …

Objective The purpose of this review is to discuss the dosage, duration and carrier for
simvastatin, and to summarize effects of topical application directly or indirectly for …

Increases in bone formation have been demonstrated in mice and rats treated with statins, a
group of molecules that increase the production of bone morphogenetic proteins-2 (BMP2) …

Hydroxymethylglutaryl-coenzyme A reductase inhibitors (statins) are widely used cholesterol-
lowering agents that also possess anti-inflammatory activities. Cysteine-rich 61 (Cyr61) and …

BACKGROUND Bone is a composite material that is composed of impure hydroxyapatite,
collagen and a variety of non-collagenous proteins, as well as embedded and adherent …

Lovastatin exhibits higher thermal stability and lower degradation rate than simvastatin.
However, the amount of research studying a lovastatin delivery device has been far less …

Scaffolds prepared from biodegradable polyurethanes (PUR) have been investigated as a
supportive matrix and delivery system for skin, cardiovascular, and bone tissue engineering …

Background: The cholesterol‐lowering drug simvastatin promotes bone formation in cell
cultures and animal models. In previous studies, devices for the controlled, localized …

US9107983B2 - Osteoconductive matrices comprising statins - Google Patents US9107983B2
- Osteoconductive matrices comprising statins - Google Patents Osteoconductive matrices …

The aim was to investigate the local osteogenic effect of fluvastatin incorporated into a
biodegradable gelatin-hydrogel (GH) scaffold. The GH scaffolds were prepared through …