Glycogen synthase kinase-3 inhibitors: preclinical and clinical focus on CNS-A decade onward

SM Arciniegas Ruiz, H Eldar-Finkelman - Frontiers in molecular …, 2022 - frontiersin.org
The protein kinase, GSK-3, participates in diverse biological processes and is now
recognized a promising drug discovery target in treating multiple pathological conditions …

[HTML][HTML] Recent advances in the pharmacology of tardive dyskinesia

SN Caroff - Clinical Psychopharmacology and Neuroscience, 2020 - ncbi.nlm.nih.gov
Tardive dyskinesia (TD) is a syndrome of abnormal involuntary movements that follows
treatment with dopamine D2-receptor antagonists. Recent approval of vesicular monoamine …

Akathisia and restless legs syndrome: solving the dopaminergic paradox

S Ferré, X Guitart, C Quiroz, W Rea… - Sleep Medicine …, 2021 - sleep.theclinics.com
Restless legs syndrome (RLS), also known as Willis-Ekbom disease, is a sensorimotor
disorder characterized by an urge to move the legs, usually accompanied by or felt to be …

Deutetrabenazine for treatment of involuntary movements in patients with tardive dyskinesia

BJ Dorfman, J Jimenez-Shahed - Expert Review of …, 2021 - Taylor & Francis
Introduction: Tardive dyskinesia (TD) is a hyperkinetic movement disorder that arises as a
complication of exposure to dopamine receptor blocking agents. Vesicular monoamine …

Genetic factors associated with tardive dyskinesia: from pre-clinical models to clinical studies

EE Tsermpini, S Redenšek, V Dolžan - Frontiers in pharmacology, 2022 - frontiersin.org
Tardive dyskinesia is a severe motor adverse event of antipsychotic medication,
characterized by involuntary athetoid movements of the trunk, limbs, and/or orofacial areas …

The role of glutamate receptors and their interactions with dopamine and other neurotransmitters in the development of tardive dyskinesia: preclinical and clinical …

AM Szota, J Scheel-Krüger - Behavioural Pharmacology, 2020 - journals.lww.com
Tardive dyskinesia is a serious, disabling, movement disorder associated with the ongoing
use of antipsychotic medication. Current evidence regarding the pathophysiology of tardive …

Age‐dependent effects of dopamine receptor inactivation on cocaine‐induced behaviors in male rats: Evidence of dorsal striatal D2 receptor supersensitivity

CA Crawford, A Teran, GI Ramirez… - Journal of …, 2019 - Wiley Online Library
Abstract N‐ethoxycarbonyl‐2‐ethoxy‐1, 2‐dihydroquinoline (EEDQ), which irreversibly
inactivates dopamine (DA) receptors, causes pronounced age‐dependent behavioral effects …

A focused update on tardive dyskinesia

PJ Blanchet - Canadian Journal of Neurological Sciences, 2020 - cambridge.org
Tardive dyskinesia (TD) is a delayed and potentially irreversible motor complication
following chronic exposure to centrally acting dopamine receptor antagonists, mainly of the …

Implication du récepteur nucléaire orphelin Nur77 (Nr4a1) dans les effets des antipsychotiques par une approche de transcriptomique chez des rats déficients en …

S Majeur - 2023 - papyrus.bib.umontreal.ca
Malgré l'usage de médicaments antipsychotiques depuis plusieurs décennies, leur
mécanisme d'action précis, autre que leur interaction avec les récepteurs dopaminergiques …

Influence of magnesium supplementation and L-type calcium channel blocker on haloperidol-induced movement disturbances

M Kronbauer, VG Metz, K Roversi, LH Milanesi… - Behavioural Brain …, 2019 - Elsevier
Haloperidol (Hal) is an antipsychotic related to movement disorders. Magnesium (Mg)
showed benefits on orofacial dyskinesia (OD), suggesting its involvement with N-methyl-D …