Intra-pancreatic fat deposition: bringing hidden fat to the fore

MS Petrov, R Taylor - Nature Reviews Gastroenterology & Hepatology, 2022 - nature.com
Abstract Development of advanced modalities for detection of fat within the pancreas has
transformed understanding of the role of intra-pancreatic fat deposition (IPFD) in health and …

Cardiovascular and metabolic heterogeneity of obesity: clinical challenges and implications for management

IJ Neeland, P Poirier, JP Després - Circulation, 2018 - Am Heart Assoc
The prevalence of obesity has increased globally over the last 2 decades. Although the body
mass index has been a convenient and simple index of obesity at the population level …

Epicardial adipose tissue may mediate deleterious effects of obesity and inflammation on the myocardium

M Packer - Journal of the American College of Cardiology, 2018 - jacc.org
Epicardial adipose tissue has unique properties that distinguish it from other depots of
visceral fat. Rather than having distinct boundaries, the epicardium shares an unobstructed …

EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterization, and clinical implication

A Goette, JM Kalman, L Aguinaga, J Akar… - Ep …, 2016 - academic.oup.com
The atria provide an important contribution to cardiac function. 1, 2 Besides their impact on
ventricular filling, they serve as a volume reservoir, host pacemaker cells and important parts …

Oxidative stress and inflammation as central mediators of atrial fibrillation in obesity and diabetes

BS Karam, A Chavez-Moreno, W Koh, JG Akar… - Cardiovascular …, 2017 - Springer
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia in humans. Several
risk factors promote AF, among which diabetes mellitus has emerged as one of the most …

Local and systemic effects of the multifaceted epicardial adipose tissue depot

G Iacobellis - Nature Reviews Endocrinology, 2015 - nature.com
Epicardial adipose tissue is a unique and multifaceted fat depot with local and systemic
effects. This tissue is distinguished from other visceral fat depots by a number of anatomical …

EHRA/HRS/APHRS/SOLAECE expert consensus on atrial cardiomyopathies: definition, characterization, and clinical implication

A Goette, JM Kalman, L Aguinaga, J Akar… - Heart …, 2017 - heartrhythmjournal.com
The atria provide an important contribution to cardiac function. 1, 2 Besides their impact on
ventricular filling, they serve as a volume reservoir, host pacemaker cells and important parts …

Effect of empagliflozin on ectopic fat stores and myocardial energetics in type 2 diabetes: the EMPACEF study

B Gaborit, P Ancel, AE Abdullah, F Maurice… - Cardiovascular …, 2021 - Springer
Background Empagliflozin is a sodium-glucose cotransporter 2 (SGLT2) inhibitor that has
demonstrated cardiovascular and renal protection in patients with type 2 diabetes (T2D). We …

Epicardial fat and atrial fibrillation: current evidence, potential mechanisms, clinical implications, and future directions

CX Wong, AN Ganesan… - European heart …, 2017 - academic.oup.com
Obesity is increasingly recognized as a major modifiable determinant of atrial fibrillation
(AF). Although body mass index and other clinical measures are useful indications of …

Childhood obesity and cardiovascular dysfunction

AT Cote, KC Harris, C Panagiotopoulos… - Journal of the American …, 2013 - jacc.org
Obesity-related cardiovascular disease in children is becoming more prevalent in
conjunction with the rise in childhood obesity. Children with obesity are predisposed to an …