Uncovering the principles of genome folding by 3D chromatin modeling

A Yildirim, L Boninsegna… - Cold Spring Harbor …, 2022 - cshperspectives.cshlp.org
Our understanding of how genomic DNA is tightly packed inside the nucleus, yet is still
accessible for vital cellular processes, has grown dramatically over recent years with …

Integrative approaches in genome structure analysis

L Boninsegna, A Yildirim, Y Zhan, F Alber - Structure, 2022 - cell.com
New technological advances in integrated imaging, sequencing-based assays, and
computational analysis have revolutionized our view of genomes in terms of their structure …

Integrative genome modeling platform reveals essentiality of rare contact events in 3D genome organizations

L Boninsegna, A Yildirim, G Polles, Y Zhan… - Nature …, 2022 - nature.com
A multitude of sequencing-based and microscopy technologies provide the means to
unravel the relationship between the three-dimensional organization of genomes and key …