Tree-based QTL mapping with expected local genetic relatedness matrices

V Link, JG Schraiber, C Fan, B Dinh, N Mancuso… - The American Journal of …, 2023 - cell.com
Understanding the genetic basis of complex phenotypes is a central pursuit of genetics.
Genome-wide association studies (GWASs) are a powerful way to find genetic loci …

A genealogical estimate of genetic relationships

C Fan, N Mancuso, CWK Chiang - The American Journal of Human …, 2022 - cell.com
The application of genetic relationships among individuals, characterized by a genetic
relationship matrix (GRM), has far-reaching effects in human genetics. However, the current …

Development of a predictive statistical pharmacological model for local anesthetic agent effects with Bayesian hierarchical model parameter estimation

T Ara, H Kitamura - Medicines, 2023 - mdpi.com
As an alternative to animal use, computer simulations are useful for predicting
pharmacokinetics and cardiovascular activities. For this purpose, we constructed a statistical …

Genetic characterization of minor carp (Labeo gonius) from Indian rivers revealed through mitochondrial ATPase 6/8 and D-loop region analysis: implications for …

S Roy, BK Behera, R VL, AK Rout, V Kumar… - Frontiers in Marine …, 2024 - frontiersin.org
India is the habitat of many freshwater fish species that make a significant contribution to
endemism. However, the native species population is declining at a very fast rate due to …

The big challenge for livestock genomics is to make sequence data pay

M Johnsson - Peer Community Journal, 2023 - peercommunityjournal.org
This paper will argue that one of the biggest challenges for livestock genomics is to make
whole-genome sequencing and functional genomics applicable to breeding practice. It …

The consequences of mitochondrial T10432C mutation in Cika Cattle: a “Potential” model for Leber's hereditary optic neuropathy

D Novosel, V Brajković, M Simčič, M Zorc… - International journal of …, 2022 - mdpi.com
While mitogenome mutations leading to pathological manifestations are rare, more than 200
such mutations have been described in humans. In contrast, pathogenic mitogenome …

Update on Magellan, the software for the analysis of a single gender lineage in pedigrees

D Hršak, V Brajković, V Cubric-Curik… - 2022 International …, 2022 - ieeexplore.ieee.org
Quantitative genetics is the field of research that links the genetic (DNA) information
(genotype) to the physical traits (phenotype), with the applications in human and livestock …

Characterizing the impact of the mutational landscape of SARS-CoV-2 on epitope presentation and CTL

D Hamelin - 2022 - papyrus.bib.umontreal.ca
The current COVID-19 pandemic, caused by Severe Acute Respiratory Syndrome
Coronavirus 2 (SARS-CoV-2), has led to upwards of 6 million deaths and nearly 680 million …

Review of the Simulators used in Pharmacology Education and Statistical Models when creating the Simulators

荒敏昭, 喜多村洋幸 - jxiv.jst.go.jp
Animal experiments have long been used as an educational tool in pharmacological
education; however, from the perspective of animal welfare, it is necessary to decrease the …