Cellular senescence, classically defined as stable cell cycle arrest, is implicated in biological
processes such as embryogenesis, wound healing and ageing. Senescent cells have a …

Senescent cell accumulation has been observed in age-associated diseases including
cardiovascular diseases. Senescent cells lack proliferative capacity and secrete senescence …

Aging leads to increased cellular senescence and is associated with decreased potency of
tissue‐specific stem/progenitor cells. Here, we have done an extensive analysis of cardiac …

Cell-based therapies represent a very promising strategy to repair and regenerate the
injured heart to prevent progression to heart failure. To date, these therapies have had …

Simple Summary Aging and frailty are complex processes implicating multifactorial
mechanisms, which demand for new therapeutic strategies against their devastating effects …

Cardiovascular disease (CVD) is the most common disease to increase as life expectancy
increases. Most high-profile pharmacological treatments for age-related CVD have led to …

Aging is considered as inevitable changes at different levels of genome, cell, and organism.
From the accumulation of DNA damages to imperfect protein homeostasis, altered cellular …

Aging is by far the dominant risk factor for the development of cardiovascular diseases,
whose prevalence dramatically increases with increasing age reaching epidemic …

Aging is a broad process that occurs as a time-dependent functional decline and tissue
degeneration in living organisms. On a smaller scale, aging also exists within organs …

The prevalence of cardiovascular diseases markedly rises with age. Cellular senescence, a
hallmark of aging, is characterized by irreversible cell cycle arrest and the manifestation of a …