1. INTRODUCTION Fluorine is the most abundant halogen in the Earth, s crust. 1 However,
only a dozen fluorinated organic compounds have been identified in nature. 2 Most of the …

Nuclear magnetic resonance (NMR) spectroscopy is a versatile tool for probing structure,
dynamics, folding, and interactions at atomic resolution. While naturally occurring …

Amyloid formation is implicated in more than 20 human diseases, yet the mechanism by
which fibrils form is not well understood. We use 2D infrared spectroscopy and isotope …

We previously reviewed the use of 19 F NMR in the broad field of chemical biology [Cobb,
SL; Murphy, CD J. Fluorine Chem. 2009, 130, 132–140] and present here a summary of the …

The 19F isotope is 100% naturally abundant and is the second most sensitive and stable
NMR-active nucleus. Unlike the ubiquitous hydrogen atom, fluorine is nearly absent in …

Fluorine is a valuable probe for investigating the interactions of biological molecules
because of its favorable NMR characteristics, its small size, and its near total absence from …

Conspectus Fluorine is all but absent from biology; however, it has proved to be a
remarkably useful element with which to modulate the activity of biological molecules and to …

In Alzheimer's disease (AD), soluble oligomers of amyloid-β (Aβ) are emerging as a crucial
entity in driving disease progression as compared to insoluble amyloid deposits. The lacuna …

Soluble amyloid-beta (Aβ) aggregates likely contribute substantially to the dementia that
characterizes Alzheimer's disease. However, despite intensive study of in vitro preparations …

Fibrillar aggregates of human islet amyloid polypeptide, hIAPP, a pathological feature seen
in some diabetes patients, are a likely causative agent for pancreatic beta‐cell toxicity …