[HTML][HTML] Potential roles and targeted therapy of the CXCLs/CXCR2 axis in cancer and inflammatory diseases
The chemokine receptor CXCR2 and its ligands are implicated in the progression of tumours
and various inflammatory diseases. Activation of the CXCLs/CXCR2 axis activates multiple …
and various inflammatory diseases. Activation of the CXCLs/CXCR2 axis activates multiple …
[HTML][HTML] Target specific tight junction modulators
J Brunner, S Ragupathy, G Borchard - Advanced drug delivery reviews, 2021 - Elsevier
Intercellular tight junctions represent a formidable barrier against paracellular drug
absorption at epithelia (eg, nasal, intestinal) and the endothelium (eg, blood–brain barrier) …
absorption at epithelia (eg, nasal, intestinal) and the endothelium (eg, blood–brain barrier) …
A large lung gene expression study identifying IL1B as a novel player in airway inflammation in COPD airway epithelial cells
G Yi, M Liang, M Li, X Fang, J Liu, Y Lai, J Chen… - Inflammation …, 2018 - Springer
Background Chronic obstructive pulmonary disease (COPD) is a chronic and progressive
lung disease characterized by a mixture of small airway disease and lung tissue …
lung disease characterized by a mixture of small airway disease and lung tissue …
An Update on Protein Kinases as Therapeutic Targets—Part I: Protein Kinase C Activation and Its Role in Cancer and Cardiovascular Diseases
Protein kinases are one of the most significant drug targets in the human proteome,
historically harnessed for the treatment of cancer, cardiovascular disease, and a growing …
historically harnessed for the treatment of cancer, cardiovascular disease, and a growing …
PKCζ, MMP‑2 and MMP‑9 expression in lung adenocarcinoma and association with a metastatic phenotype
X Cai, H Zhu, Y Li - Molecular medicine reports, 2017 - spandidos-publications.com
The aim of the present study was to investigate protein kinase C ζ type (PKCζ), matrix
metalloproteinase (MMP)‑2 and MMP‑9 expression in lung adenocarcinoma and to define …
metalloproteinase (MMP)‑2 and MMP‑9 expression in lung adenocarcinoma and to define …
[HTML][HTML] Surfaxin attenuates PM2. 5-induced airway inflammation via restoring surfactant proteins in rats exposed to cigarette smoke
XW Sun, YN Lin, YJ Ding, SQ Li, HP Li, JP Zhou… - Environmental …, 2022 - Elsevier
Epidemiologic studies have shown that the fine particulate matter 2.5 (PM2. 5) exaggerates
chronic airway inflammation involving in acute exacerbation of chronic obstructive …
chronic airway inflammation involving in acute exacerbation of chronic obstructive …
PRKCD as a potential therapeutic target for chronic obstructive pulmonary disease
S Li, Q Huang, D Zhou, B He - International immunopharmacology, 2022 - Elsevier
Background Chronic obstructive pulmonary disease (COPD) is a common respiratory
disease characterized by progressive airflow limitation and abnormal lung function due to …
disease characterized by progressive airflow limitation and abnormal lung function due to …
[HTML][HTML] Impact of peptide permeation enhancer on tight junctions opening cellular mechanisms
J Brunner, D Schvartz, A Gouiller, A Hainard… - … and Biophysics Reports, 2022 - Elsevier
The myristoylated pentapeptide, L-R5, contains an amino acid sequence of the zeta
inhibitory peptide (ZIP) portion (pseudosubstrate) of protein kinase C zeta (PKC ζ). As PKC ζ …
inhibitory peptide (ZIP) portion (pseudosubstrate) of protein kinase C zeta (PKC ζ). As PKC ζ …
Verproside, the Most Active Ingredient in YPL-001 Isolated from Pseudolysimachion rotundum var. subintegrum, Decreases Inflammatory Response by Inhibiting …
ES Oh, HW Ryu, MO Kim, JW Lee, YN Song… - International Journal of …, 2023 - mdpi.com
Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease
which causes breathing problems. YPL-001, consisting of six iridoids, has potent inhibitory …
which causes breathing problems. YPL-001, consisting of six iridoids, has potent inhibitory …
Mechanical strain mimicking breathing amplifies alterations in gene expression induced by SiO2 NPs in lung epithelial cells
C Schmitz, J Welck, I Tavernaro, M Grinberg… - …, 2019 - Taylor & Francis
The effects of engineered nanomaterials on human health are still intensively studied in
order to facilitate their safe application. However, relatively little is known how mechanical …
order to facilitate their safe application. However, relatively little is known how mechanical …