Anti-angiogenic therapy is an old method to fight cancer that aims to abolish the nutrient and
oxygen supply to the tumor cells through the decrease of the vascular network and the …

Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

Liver cancer is the second leading cause of cancer mortality worldwide, causing more than
700,000 deaths annually. Because of the wide landscape of genomic alterations and limited …

siRNA is a promising therapeutic solution to address gene overexpression or mutations as a
post-transcriptional gene regulation process for several pathological conditions such as viral …

Placental growth factor (PlGF) is an increasingly important molecule in the prediction,
diagnosis and treatment of pre-eclampsia. It has pro-angiogenic effects on the feto-placental …

Excessive abnormal angiogenesis plays a pivotal role in tumor progression and is a
hallmark of solid tumors. This process is driven by an imbalance between pro-and anti …

Retinal microvasculature is crucial for the visual function of the neural retina. Pericytes and
endothelial cells (ECs) are the two main cellular constituents in the retinal microvessels …

Tumours require a vascular supply to grow and can achieve this via the expression of pro-
angiogenic growth factors, including members of the vascular endothelial growth factor …

Blood vessels deliver oxygen and nutrients to every part of the body, but also nourish
diseases such as cancer. Over the past decade, our understanding of the molecular …

The vascular endothelial growth factor (VEGF) and its receptor (VEGFR) have been shown
to play major roles not only in physiological but also in most pathological angiogenesis …