Sensorineural hearing loss (SNHL) can either be genetically inherited or acquired as a
result of aging, noise exposure, or ototoxic drugs. Although the precise pathophysiological …

Cisplatin is a commonly used chemotherapeutic agent with proven efficacy in treating
various malignancies, including testicular, ovarian, cervical, breast, bladder, head and neck …

Hearing disorders pose significant challenges to individuals experiencing them and their
overall quality of life, emphasizing the critical need for advanced pharmacological …

Hair cells (HCs) are specialised sensory receptors residing in the neurosensory epithelia of
inner ear sense organs. The precise morphological and physiological properties of HCs …

The biomedical community is rapidly developing COVID-19 drugs to bring much-need
therapies to market, with over 900 drugs and drug combinations currently in clinical trials …

Abstract According to the World Health Organization's world report on hearing, nearly 2.5
billion people worldwide will suffer from hearing loss by 2050, which may contribute to a …

Deafness is a highly heterogeneous disorder which stems, for 50%, from genetic origins.
Sensory transduction relies mainly on sensory hair cells of the cochlea, in the inner ear …

Cisplatin is a chemotherapy drug that causes permanent hearing loss by injuring cochlear
hair cells. Hair cell mitochondria have emerged as potential mediators of hair cell …

Cisplatin is an effective anticancer agent, but also causes permanent hearing loss by
damaging hair cells—the sensory receptors essential for hearing. There is an urgent clinical …

Hearing or balance loss are disabling conditions that have a serious impact in those
suffering them, especially when they appear in children. Their ultimate cause is frequently …