In Silico Analyses on the Comparative Potential of Therapeutic Human Monoclonal Antibodies Against Newly Emerged SARS-CoV-2 Variants Bearing Mutant Spike …

NC Das, P Chakraborty, J Bayry… - Frontiers in …, 2022 - frontiersin.org
Since the start of the pandemic, SARS-CoV-2 has already infected more than 250 million
people globally, with more than five million fatal cases and huge socio-economic losses. In …

Exploring NS3/4A, NS5A and NS5B proteins to design conserved subunit multi-epitope vaccine against HCV utilizing immunoinformatics approaches

A Ikram, T Zaheer, FM Awan, A Obaid, A Naz, R Hanif… - Scientific reports, 2018 - nature.com
Hepatitis C virus (HCV) vaccines, designed to augment specific T-cell responses, have been
designated as an important aspect of effective antiviral treatment. However, despite the …

Advances in hepatitis C virus vaccines, part two: advances in hepatitis C virus vaccine formulations and modalities

F Roohvand, N Kossari - Expert opinion on therapeutic patents, 2012 - Taylor & Francis
Introduction: Developing a vaccine against HCV is an important medical and global priority.
Unavailability and potential dangers associated with using attenuated HCV viral particles for …

Immuno-informatics analysis of PAKISTAN-based HCV subtype-3a for chimeric polypeptide vaccine design

S Ahmad, F Shahid, M Tahir ul Qamar, HU Rehman… - Vaccines, 2021 - mdpi.com
Hepatitis C virus (HCV) causes chronic and acute hepatitis infections. As there is extreme
variability in the HCV genome, no approved HCV vaccine has been available so far. An …

Advances in hepatitis C virus vaccines, Part one: Advances in basic knowledge for hepatitis C virus vaccine design

F Roohvand, N Kossari - Expert opinion on therapeutic patents, 2011 - Taylor & Francis
Introduction: Around 3% of the world population is infected with HCV, with 3–4 million newly
infected subjects added to this reservoir every year. At least 10% of these people will …

[HTML][HTML] The generation of a simian adenoviral vectored HCV vaccine encoding genetically conserved gene segments to target multiple HCV genotypes

A von Delft, TA Donnison, J Lourenço, C Hutchings… - Vaccine, 2018 - Elsevier
Abstract Background Hepatitis C virus (HCV) genomic variability is a major challenge to the
generation of a prophylactic vaccine. We have previously shown that HCV specific T-cell …

Computational exploration and design of a multi-epitopes vaccine construct against Chlamydia psittaci

AM Alsubaiyel, SI Bukhari - Journal of Biomolecular Structure and …, 2023 - Taylor & Francis
Chlamydia psittaci is an intracellular pathogen and causes variety of deadly infections in
humans. Antibiotics are effective against C. psittaci however high percentage of resistant …

Co-expression of hepatitis C virus polytope–HBsAg and p19-silencing suppressor protein in tobacco leaves

S Mohammadzadeh, F Roohvand… - Pharmaceutical …, 2016 - Taylor & Francis
Context: Plants transformed by virus-based vectors have emerged as promising tools to
rapidly express large amounts and inexpensive antigens in transient condition. Objective …

Fusion of HBsAg and prime/boosting augment Th1 and CTL responses to HCV polytope DNA vaccine

A Memarnejadian, F Roohvand - Cellular immunology, 2010 - Elsevier
Correlation of hepatitis C virus (HCV) spontaneous resolution with Th1 and CD8+ CTL
responses during natural infection implies the potentiality of poly-CTL-epitopic HCV …

TROLLOPE: A novel sequence-based stacked approach for the accelerated discovery of linear T-cell epitopes of hepatitis C virus

P Charoenkwan, S Waramit, P Chumnanpuen… - Plos one, 2023 - journals.plos.org
Hepatitis C virus (HCV) infection is a concerning health issue that causes chronic liver
diseases. Despite many successful therapeutic outcomes, no effective HCV vaccines are …