Natural killer cells in clinical development as non-engineered, engineered, and combination therapies
N Lamers-Kok, D Panella, AM Georgoudaki… - Journal of Hematology & …, 2022 - Springer
Natural killer (NK) cells are unique immune effectors able to kill cancer cells by direct
recognition of surface ligands, without prior sensitization. Allogeneic NK transfer is a highly …
recognition of surface ligands, without prior sensitization. Allogeneic NK transfer is a highly …
Alternative to FBS in animal cell culture-An overview and future perspective
KS Chelladurai, JDS Christyraj, K Rajagopalan… - Heliyon, 2021 - cell.com
Fetal bovine serum (FBS) is a widely used growth supplement in the in vitro culturing of
animal and human cells, tissues and organs, notably due to the occurrence of abundant …
animal and human cells, tissues and organs, notably due to the occurrence of abundant …
Large-scale cultured meat production: Trends, challenges and promising biomanufacturing technologies
L Chen, D Guttieres, A Koenigsberg, PW Barone… - Biomaterials, 2022 - Elsevier
Food systems of the future will need to face an increasingly clear reality–that a protein-rich
diet is essential for good health, but traditional meat products will not suffice to ensure safety …
diet is essential for good health, but traditional meat products will not suffice to ensure safety …
Fetal bovine serum (FBS): past–present–future
J Van der Valk, K Bieback, C Buta, B Cochrane… - ALTEX-Alternatives to …, 2018 - altex.org
The supplementation of culture medium with fetal bovine serum (FBS, also referred to as
“fetal calf serum”) is still common practice in cell culture applications. Due to a number of …
“fetal calf serum”) is still common practice in cell culture applications. Due to a number of …
Manufacturing of primed mesenchymal stromal cells for therapy
JQ Yin, J Zhu, JA Ankrum - Nature biomedical engineering, 2019 - nature.com
Mesenchymal stromal cells (MSCs) for basic research and clinical applications are
manufactured and developed as unique cell products by many different manufacturers and …
manufactured and developed as unique cell products by many different manufacturers and …
Mammalian cell culture for production of recombinant proteins: A review of the critical steps in their biomanufacturing
R O'Flaherty, A Bergin, E Flampouri, LM Mota… - Biotechnology …, 2020 - Elsevier
The manufacturing of recombinant protein is traditionally undertaken in mammalian cell
culture. Today, speed, cost and safety are the primary considerations for process …
culture. Today, speed, cost and safety are the primary considerations for process …
Increased mesenchymal stem cell functionalization in three-dimensional manufacturing settings for enhanced therapeutic applications
D Kouroupis, D Correa - Frontiers in bioengineering and …, 2021 - frontiersin.org
Mesenchymal stem/stromal cell (MSC) exist within their in vivo niches as part of
heterogeneous cell populations, exhibiting variable stemness potential and supportive …
heterogeneous cell populations, exhibiting variable stemness potential and supportive …
Optimization of mesenchymal stromal cell (MSC) manufacturing processes for a better therapeutic outcome
ME Fernández-Santos, M Garcia-Arranz… - Frontiers in …, 2022 - frontiersin.org
MSCs products as well as their derived extracellular vesicles, are currently being explored
as advanced biologics in cell-based therapies with high expectations for their clinical use in …
as advanced biologics in cell-based therapies with high expectations for their clinical use in …
Technological and structural aspects of scaffold manufacturing for cultured meat: recent advances, challenges, and opportunities
In vitro cultured meat is an emerging area of research focus with an innovative approach
through tissue engineering (ie, cellular engineering) to meet the global food demand. The …
through tissue engineering (ie, cellular engineering) to meet the global food demand. The …
Translating mesenchymal stem cell and their exosome research into GMP compliant advanced therapy products: Promises, problems and prospects
CY Ma, Y Zhai, CT Li, J Liu, X Xu… - Medicinal Research …, 2024 - Wiley Online Library
Mesenchymal stem cells (MSCs) are one of the few stem cell types used in clinical practice
as therapeutic agents for immunomodulation and ischemic tissue repair, due to their unique …
as therapeutic agents for immunomodulation and ischemic tissue repair, due to their unique …