The extracellular matrix is a fundamental, core component of all tissues and organs, and is
essential for the existence of multicellular organisms. From the earliest stages of organism …

This review investigates the significant role polysaccharide particles play in functional drug
delivery. The importance of these systems is due to the wide variety of polysaccharides and …

Radiotherapy plays a central part in curing cancer. For decades, most research on
improving treatment outcomes has focused on modulating radiation-induced biological …

Septic cardiomyopathy is a key feature of sepsis-associated cardiovascular failure. Despite
the lack of consistent diagnostic criteria, patients typically exhibit ventricular dilatation …

Cancer metastasis is the dissemination of tumor cells to new sites, resulting in the formation
of secondary tumors. This process is complex and is spatially and temporally regulated by …

Heparan sulfate (HS) proteoglycans (PGs) are ubiquitously expressed on cell surfaces and
in the extracellular matrix of most animal tissues, having essential functions in development …

Polysaccharide-based nanoparticles have fascinated attention as a vesicle of different
pharmaceutical agents due to their unique multi-functional groups in addition to their …

Osteosarcoma (OS) is the most common primary bone malignancy and responsible for
considerable morbidity and mortality due to its high rates of pulmonary metastasis. Although …

Because of its impact on multiple biological pathways, heparanase has emerged as a major
regulator of cancer, inflammation and other disease processes. Heparanase accomplishes …

Emerging evidence indicates that exosomes play a key role in tumor-host cross-talk and that
exosome secretion, composition, and functional capacity are altered as tumors progress to …