The matrix in cancer
TR Cox - Nature Reviews Cancer, 2021 - nature.com
The extracellular matrix is a fundamental, core component of all tissues and organs, and is
essential for the existence of multicellular organisms. From the earliest stages of organism …
essential for the existence of multicellular organisms. From the earliest stages of organism …
Review of polysaccharide particle-based functional drug delivery
This review investigates the significant role polysaccharide particles play in functional drug
delivery. The importance of these systems is due to the wide variety of polysaccharides and …
delivery. The importance of these systems is due to the wide variety of polysaccharides and …
The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence
Radiotherapy plays a central part in curing cancer. For decades, most research on
improving treatment outcomes has focused on modulating radiation-induced biological …
improving treatment outcomes has focused on modulating radiation-induced biological …
The septic heart: current understanding of molecular mechanisms and clinical implications
Septic cardiomyopathy is a key feature of sepsis-associated cardiovascular failure. Despite
the lack of consistent diagnostic criteria, patients typically exhibit ventricular dilatation …
the lack of consistent diagnostic criteria, patients typically exhibit ventricular dilatation …
Cancer metastasis: the role of the extracellular matrix and the heparan sulfate proteoglycan perlecan
Cancer metastasis is the dissemination of tumor cells to new sites, resulting in the formation
of secondary tumors. This process is complex and is spatially and temporally regulated by …
of secondary tumors. This process is complex and is spatially and temporally regulated by …
Heparan sulfate: biosynthesis, structure, and function
JP Li, M Kusche-Gullberg - International review of cell and molecular …, 2016 - Elsevier
Heparan sulfate (HS) proteoglycans (PGs) are ubiquitously expressed on cell surfaces and
in the extracellular matrix of most animal tissues, having essential functions in development …
in the extracellular matrix of most animal tissues, having essential functions in development …
Polysaccharide based nanogels in the drug delivery system: Application as the carrier of pharmaceutical agents
Polysaccharide-based nanoparticles have fascinated attention as a vesicle of different
pharmaceutical agents due to their unique multi-functional groups in addition to their …
pharmaceutical agents due to their unique multi-functional groups in addition to their …
The role of extracelluar matrix in osteosarcoma progression and metastasis
J Cui, D Dean, FJ Hornicek, Z Chen, Z Duan - Journal of Experimental & …, 2020 - Springer
Osteosarcoma (OS) is the most common primary bone malignancy and responsible for
considerable morbidity and mortality due to its high rates of pulmonary metastasis. Although …
considerable morbidity and mortality due to its high rates of pulmonary metastasis. Although …
Heparanase regulation of cancer, autophagy and inflammation: new mechanisms and targets for therapy
RD Sanderson, M Elkin, AC Rapraeger, N Ilan… - The FEBS …, 2017 - Wiley Online Library
Because of its impact on multiple biological pathways, heparanase has emerged as a major
regulator of cancer, inflammation and other disease processes. Heparanase accomplishes …
regulator of cancer, inflammation and other disease processes. Heparanase accomplishes …
Heparanase regulates secretion, composition, and function of Tumor Cell-derived Exosomes*♦
CA Thompson, A Purushothaman, VC Ramani… - Journal of Biological …, 2013 - ASBMB
Emerging evidence indicates that exosomes play a key role in tumor-host cross-talk and that
exosome secretion, composition, and functional capacity are altered as tumors progress to …
exosome secretion, composition, and functional capacity are altered as tumors progress to …