Detecting tumor metastases: the road to therapy starts here
Metastasis is the complex process by which primary tumor cells migrate and establish
secondary tumors in an adjacent or distant location in the body. Early detection of metastatic …
secondary tumors in an adjacent or distant location in the body. Early detection of metastatic …
Targeted polymeric nanoparticles for cancer gene therapy
In this article, advances in designing polymeric nanoparticles for targeted cancer gene
therapy are reviewed. Characterization and evaluation of biomaterials, targeting ligands …
therapy are reviewed. Characterization and evaluation of biomaterials, targeting ligands …
(2S)-2-(3-(1-carboxy-5-(4-211At-astatobenzamido) pentyl) ureido)-pentanedioic acid for PSMA-targeted α-particle radiopharmaceutical therapy
Alpha-particle emitters have a high linear energy transfer and short range, offering the
potential for treating micrometastases while sparing normal tissues. We developed a urea …
potential for treating micrometastases while sparing normal tissues. We developed a urea …
Medical imaging in personalised medicine: a white paper of the research committee of the European Society of Radiology (ESR)
… of Radiology (ESR) communications@ myesr. org - Insights into …, 2015 - Springer
The future of medicine lies in early diagnosis and individually tailored treatments, a concept
that has been designated 'personalised medicine'(PM), which aims to deliver the right …
that has been designated 'personalised medicine'(PM), which aims to deliver the right …
MDA-9/Syntenin in the tumor and microenvironment defines prostate cancer bone metastasis
Bone metastasis is a frequent and incurable consequence of advanced prostate cancer
(PC). An interplay between disseminated tumor cells and heterogeneous bone resident cells …
(PC). An interplay between disseminated tumor cells and heterogeneous bone resident cells …
Targeted delivery and sustained antitumor activity of triptolide through glucose conjugation
Triptolide, a key ingredient from the traditional Chinese medicinal plant thunder god vine,
which has been used to treat inflammation and autoimmune diseases for centuries, has …
which has been used to treat inflammation and autoimmune diseases for centuries, has …
Evaluation of PSMA-targeted PAMAM dendrimer nanoparticles in a murine model of prostate cancer
The prostate-specific membrane antigen (PSMA) is a validated target for detection and
management of prostate cancer (PC). It has also been utilized for targeted drug delivery …
management of prostate cancer (PC). It has also been utilized for targeted drug delivery …
Critical length of PEG grafts on lPEI/DNA nanoparticles for efficient in vivo delivery
Nanoparticle-mediated gene delivery is a promising alternative to viral methods; however,
its use in vivo, particularly following systemic injection, has suffered from poor delivery …
its use in vivo, particularly following systemic injection, has suffered from poor delivery …
A unique core–shell structured, glycol chitosan-based nanoparticle achieves cancer-selective gene delivery with reduced off-target effects
The inherent instability of nucleic acids within serum and the tumor microenvironment
necessitates a suitable vehicle for non-viral gene delivery to malignant lesions. A specificity …
necessitates a suitable vehicle for non-viral gene delivery to malignant lesions. A specificity …
Recombinant MDA-7/IL24 suppresses prostate cancer bone metastasis through downregulation of the Akt/Mcl-1 pathway
AK Pradhan, P Bhoopathi, S Talukdar, XN Shen… - Molecular cancer …, 2018 - AACR
Prostate cancer is a principal cause of cancer-associated morbidity in men. Although 5-year
survival of patients with localized prostate cancer approaches 100%, survival decreases …
survival of patients with localized prostate cancer approaches 100%, survival decreases …