Detecting tumor metastases: the road to therapy starts here

ME Menezes, SK Das, I Minn, L Emdad… - Advances in cancer …, 2016 - Elsevier
Metastasis is the complex process by which primary tumor cells migrate and establish
secondary tumors in an adjacent or distant location in the body. Early detection of metastatic …

Targeted polymeric nanoparticles for cancer gene therapy

J Kim, DR Wilson, CG Zamboni… - Journal of drug targeting, 2015 - Taylor & Francis
In this article, advances in designing polymeric nanoparticles for targeted cancer gene
therapy are reviewed. Characterization and evaluation of biomaterials, targeting ligands …

(2S)-2-(3-(1-carboxy-5-(4-211At-astatobenzamido) pentyl) ureido)-pentanedioic acid for PSMA-targeted α-particle radiopharmaceutical therapy

AP Kiess, IL Minn, G Vaidyanathan… - Journal of Nuclear …, 2016 - Soc Nuclear Med
Alpha-particle emitters have a high linear energy transfer and short range, offering the
potential for treating micrometastases while sparing normal tissues. We developed a urea …

Medical imaging in personalised medicine: a white paper of the research committee of the European Society of Radiology (ESR)

… of Radiology (ESR) communications@ myesr. org - Insights into …, 2015 - Springer
The future of medicine lies in early diagnosis and individually tailored treatments, a concept
that has been designated 'personalised medicine'(PM), which aims to deliver the right …

MDA-9/Syntenin in the tumor and microenvironment defines prostate cancer bone metastasis

S Maji, AK Pradhan, A Kumar… - Proceedings of the …, 2023 - National Acad Sciences
Bone metastasis is a frequent and incurable consequence of advanced prostate cancer
(PC). An interplay between disseminated tumor cells and heterogeneous bone resident cells …

Targeted delivery and sustained antitumor activity of triptolide through glucose conjugation

QL He, I Minn, Q Wang, P Xu, SA Head… - Angewandte …, 2016 - Wiley Online Library
Triptolide, a key ingredient from the traditional Chinese medicinal plant thunder god vine,
which has been used to treat inflammation and autoimmune diseases for centuries, has …

Evaluation of PSMA-targeted PAMAM dendrimer nanoparticles in a murine model of prostate cancer

WG Lesniak, S Boinapally, SR Banerjee… - Molecular …, 2019 - ACS Publications
The prostate-specific membrane antigen (PSMA) is a validated target for detection and
management of prostate cancer (PC). It has also been utilized for targeted drug delivery …

Critical length of PEG grafts on lPEI/DNA nanoparticles for efficient in vivo delivery

JM Williford, MM Archang, I Minn, Y Ren… - ACS Biomaterials …, 2016 - ACS Publications
Nanoparticle-mediated gene delivery is a promising alternative to viral methods; however,
its use in vivo, particularly following systemic injection, has suffered from poor delivery …

A unique core–shell structured, glycol chitosan-based nanoparticle achieves cancer-selective gene delivery with reduced off-target effects

B Cheng, HH Ahn, H Nam, Z Jiang, FJ Gao, I Minn… - Pharmaceutics, 2022 - mdpi.com
The inherent instability of nucleic acids within serum and the tumor microenvironment
necessitates a suitable vehicle for non-viral gene delivery to malignant lesions. A specificity …

Recombinant MDA-7/IL24 suppresses prostate cancer bone metastasis through downregulation of the Akt/Mcl-1 pathway

AK Pradhan, P Bhoopathi, S Talukdar, XN Shen… - Molecular cancer …, 2018 - AACR
Prostate cancer is a principal cause of cancer-associated morbidity in men. Although 5-year
survival of patients with localized prostate cancer approaches 100%, survival decreases …