Multi-component reactions (MCRs) are considered to be an important methodological
arsenal in synthetic and medicinal chemistry. These reactions have been strategically …

Tetrazole derivatives are a prime class of heterocycles, very important to medicinal
chemistry and drug design due to not only their bioisosterism to carboxylic acid and amide …

Polyheterocycles are one of the most desired synthetic targets due to their numerous and
valuable applications in various fields. Multicomponent reactions (MCRs) are highly …

Although isocyanide-based multicomponent reactions were proven to be simple, elegant
and facile strategies for the synthesis of highly valuable nitrogen-containing heterocycles …

An energy-saving and eco-friendly method for the efficient construction of various tri-and
tetra-substituted pyrrolecarbonitriles through ultrasound-assisted multicomponent tandem …

Tetrazole is a most versatile pharmacophore of which more than twenty FDAapproved drugs
have been marketed globally for the management of various diseases. In spite of many …

The synthesis of heterocyclic compounds has drawn considerable attention in the scientific
community due to their existence in the majority of medicinal & pharmaceutically important …

Atropisomers have attracted a great deal of attention lately due to their numerous
applications in organic synthesis and to their employment in drug discovery. However, the …

The Escherichia coli neutral M1-aminopeptidase (ePepN) is a novel target identified for the
development of antimicrobials. Here we describe a solid-phase multicomponent approach …

A new, efficient, green, endogenous water-triggered, solvent-and catalyst-free ultrasound-
assisted one-pot Groebke–Blackburn–Bienaymé reaction/SNAr/ring-chain azido …