Organisms are equipped with regulatory systems that display a variety of dynamical
behavior ranging from simple stable steady states, to switching and multistability, to …

The fundamental mechanisms that control and regulate biological organisms exhibit a
surprising level of complexity. Oscillators are perhaps the simplest motifs that produce time …

Understanding the dynamics and variability of protein circuitry requires accurate
measurements in living cells as well as theoretical models. To address this, we employed …

DNA damage initiates a series of p53 pulses. Although much is known about the interactions
surrounding p53, little is known about which interactions contribute to p53's dynamical …

The tumor suppressor p53 plays a crucial role in cellular response to various stresses.
Recent experiments have shown that p53 level exhibits a series of pulses after DNA …

Living organisms are constantly exposed to DNA damage, and optimal repair is therefore
crucial. A characteristic hallmark of the response is the formation of sub-compartments …

A number of genes change their expression pattern dynamically by displaying oscillations.
In a few important cases these oscillations are sustained and can work as molecular clocks …

The NF-κB signaling system is involved in a variety of cellular processes including immune
response, inflammation, and apoptosis. Recent experiments have found oscillations in the …

We investigate the dynamical properties of a simple four-variable model describing the
interactions between the tumour suppressor protein p53, its main negative regulator Mdm2 …

The development of new techniques to quantitatively measure gene expression in cells has
shed light on a number of systems that display oscillations in protein concentration. Here we …