Glycoconjugates are major constituents of mammalian cells that are formed via covalent
conjugation of carbohydrates to other biomolecules like proteins and lipids and often …

Glycosylation is a ubiquitous post-translational modification responsible for a multitude of
crucial biological roles. As obligate parasites, viruses exploit host-cell machinery to …

Antibodies capable of neutralizing HIV-1 often target variable regions 1 and 2 (V1V2) of the
HIV-1 envelope, but the mechanism of their elicitation has been unclear. Here we define the …

The HIV-1 envelope (Env) mediates viral entry into host cells. To enable the direct imaging
of conformational dynamics within Env, we introduced fluorophores into variable regions of …

Adeno-associated viral vector-mediated transfer of DNA coding for broadly neutralizing anti-
HIV antibodies (bnAbs) offers an alternative to attempting to induce protection by vaccination …

HIV-1 entry into CD4+ target cells is mediated by cleaved envelope glycoprotein (Env)
trimers that have been challenging to characterize structurally. Here, we describe the crystal …

The HIV-1 fusion peptide, comprising 15 to 20 hydrophobic residues at the N terminus of the
Env-gp41 subunit, is a critical component of the virus-cell entry machinery. Here, we report …

Abstract Model-based analyses of natural selection often categorize sites into a relatively
small number of site classes. Forcing each site to belong to one of these classes places …

Viral protein glycosylation represents a successful strategy employed by the parasite to take
advantage of host–cell machinery for modification of its own proteins. The resulting glycans …

Broadly neutralizing antibodies (bnAbs) targeting the trimer apex of HIV envelope are
favored candidates for vaccine design and immunotherapy because of their great …