Chronic liver disease when accompanied by underlying fibrosis, is characterized by an
accumulation of extracellular matrix (ECM) proteins and chronic inflammation. Although …

Overview IL-7 is a member of the family of cytokines with four anti-parallel α helixes that bind
Type I cytokine receptors. It is produced by stromal cells and is required for development …

The naïve and memory T lymphocyte pools are maintained through poorly understood
homeostatic mechanisms that may include signaling via cytokine receptors. We show that …

Cells need to be anchored to extracellular matrix (ECM) to survive, yet the role of ECM in
guiding developmental processes, tissue homeostasis, and aging has long been …

Interleukin-7 (IL-7) was initially isolated more than 10 years ago. 1-4 Nevertheless, the
complete set of physiologic roles for this cytokine, especially those involving lymphocyte …

Tissue injury caused by infection or physical damage evokes inflammatory reactions and
events that are necessary for regaining homeostasis. Central to these events is the …

Interleukin-7 (IL-7), a product of stromal cells, provides critical signals to lymphoid cells at
early stages in their development. Two types of cellular responses to IL-7 have been …

Human soluble interleukin-7 receptor (sIL7R) α circulates in high molar excess compared
with IL-7, but its biology remains unclear. We demonstrate that sIL7Rα has moderate affinity …

While physiological levels of IL-7 are essential for T cell proliferation, survival and co-
stimulation, its escalated concentration has been associated with autoimmune diseases …

Objective In∼ 25% of synovial tissues from rheumatoid arthritis (RA) patients, infiltrates of T
cells, B cells, and follicular dendritic cells (FDCs) are spatially organized into structures …