Acute kidney injury (AKI) arising from diverse etiologies is characterized by mitochondrial
dysfunction. The peroxisome proliferator-activated receptor γ coactivator-1alpha (PGC1α), a …

Glucose and fatty acids are the major sources of energy for human body. Cholesterol, the
most abundant sterol in mammals, is a key component of cell membranes although it does …

Mitochondrial dysfunction has been implicated in the development of insulin resistance (IR);
however, a large variety of association and intervention studies as well as genetic …

Type 2 diabetes mellitus is characterized by the dysregulation of glucose homeostasis,
resulting in hyperglycaemia. Although current diabetes treatments have exhibited some …

Mitophagy is a fundamental quality control mechanism of mitochondria. Its regulatory
mechanisms and pathological implications remain poorly understood. Here, via a …

Background Platinum-based chemotherapy remains the standard of care for most lung
cancer cases. However chemoresistance is often developed during the treatment, limiting …

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s),
consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related …

Neurodegenerative disorders (NDDs) are characterized by progressive loss of selectively
vulnerable neuronal populations and myelin sheath, leading to behavioral and cognitive …

Metabolic adaptations are emerging hallmarks of cancer progression and cellular
transformation. Clear cell renal cell carcinoma (ccRCC) is a metabolic disease defined …

Aging is defined as changes in an organism over time. The proportion of the aged
population is markedly increasing worldwide. The kidney, as an essential organ with a high …