About twenty years ago, the functional lipid raft model of the plasma membrane was
published. It took into account decades of research showing that cellular membranes are not …

The phagocytic response of innate immune cells such as macrophages is defined by the
activation of complex signaling networks that are stimulated by microbial contact. Many …

In this study, we used cryoelectron microscopy to determine the structures of the Flotillin
protein complex, part of the Stomatin, Prohibitin, Flotillin, and HflK/C (SPFH) superfamily …

Endocytosis, phagocytosis, and macropinocytosis are fundamental processes that enable
cells to sample their environment, eliminate pathogens and apoptotic bodies, and regulate …

Following phagocytosis, the nascent phagosome undergoes maturation to become a
phagolysosome with an acidic, hydrolytic, and often oxidative lumen that can efficiently kill …

The ability to process microbial antigens and present them at the surface of cells is an
important aspect of our innate ability to clear infections. It is generally accepted that antigens …

As intracellular parasites, viruses rely heavily on the use of numerous cellular machineries
for completion of their replication cycle. The recent discovery of the heterogeneous …

Membrane lipids were once thought to be homogenously distributed in the 2D surface of a
membrane, but the lipid raft theory suggests that cholesterol and sphingolipids partition …

Lipid rafts are plasma membrane microdomains enriched in cholesterol and sphingolipids
that are involved in the lateral compartmentalization of molecules at the cell surface …

Diverse cellular processes are driven by motor proteins that are recruited to and generate
force on lipid membranes. Surprisingly little is known about how membranes control the …