Mitochondria are key determinants of cellular health. However, the functional role of
mitochondria varies from cell to cell depending on the relative demands for energy …

Historically, mitochondrial reactive oxygen species (mROS) were thought to exclusively
cause cellular damage and lack a physiological function. Accumulation of ROS and …

Store-operated calcium channels (SOCs) are a major pathway for calcium signaling in
virtually all metozoan cells and serve a wide variety of functions ranging from gene …

Calcium signals in cells of the immune system participate in the regulation of cell
differentiation, gene transcription and effector functions. An increase in intracellular levels of …

Mitochondria can govern local concentrations of second messengers, such as reactive
oxygen species (ROS), and mitochondrial translocation to discrete subcellular regions may …

Ca2+ entry into cells of the peripheral immune system occurs through highly Ca2+-selective
channels known as CRAC (calcium release-activated calcium) channels. CRAC channels …

The interplay between Ca 2+ and reactive oxygen species (ROS) signaling pathways is well
established, with reciprocal regulation occurring at a number of subcellular locations. Many …

Mitochondria are multifunctional organelles that not only produce energy for the cell, but are
also important for cell signalling, apoptosis and many biosynthetic pathways. In most cell …

Calcium oscillations suppress mitochondrial movements along the microtubules to support
on-demand distribution of mitochondria. To activate this mechanism, Ca2+ targets a yet …

Abstract Optic atrophy 1 (OPA1) is a mitochondrial inner membrane protein that has an
important role in mitochondrial fusion and structural integrity. Dysfunctional OPA1 mutations …