Advancing tissue decellularized hydrogels for engineering human organoids

BS Moura, MV Monteiro, LP Ferreira… - Advanced Functional …, 2022 - Wiley Online Library
The extracellular matrix plays a critical role in bioinstructing cellular self‐assembly and
spatial (re) configuration processes that culminate in human organoids in vitro generation …

Insights into the use of genetically modified decellularized biomaterials for tissue engineering and regenerative medicine

D Zhu, Z Jiang, N Li, X Wang, L Ren, Y Ye… - Advanced Drug Delivery …, 2022 - Elsevier
Various modifications have been performed on biomaterials to improve their applications in
tissue engineering and regenerative medicine. However, the challenges of immunogenicity …

Spatio-temporal dynamics enhance cellular diversity, neuronal function and further maturation of human cerebral organoids

P Saglam-Metiner, U Devamoglu, Y Filiz… - Communications …, 2023 - nature.com
The bioengineerined and whole matured human brain organoids stand as highly valuable
three-dimensional in vitro brain-mimetic models to recapitulate in vivo brain development …

[HTML][HTML] Rise of tissue-and species-specific 3D bioprinting based on decellularized extracellular matrix-derived bioinks and bioresins

L Elomaa, A Almalla, E Keshi, KH Hillebrandt… - Biomaterials and …, 2023 - Elsevier
Thanks to its natural complexity and functionality, decellularized extracellular matrix (dECM)
serves as an excellent foundation for creating highly cell-compatible bioinks and bioresins …

Humanized brain organoids-on-chip integrated with sensors for screening neuronal activity and neurotoxicity

P Saglam-Metiner, E Yildirim, C Dincer, O Basak… - Microchimica Acta, 2024 - Springer
The complex structure and function of the human central nervous system that develops from
the neural tube made in vitro modeling quite challenging until the discovery of brain …

Characterization of a decellularized pericardium extracellular matrix hydrogel for regenerative medicine: insights on animal-to-animal variability

D Di Francesco, E Marcello, S Casarella… - … in bioengineering and …, 2024 - frontiersin.org
In the past years, the use of hydrogels derived from decellularized extracellular matrix
(dECM) for regenerative medicine purposes has significantly increased. The intrinsic …

Differentiation of neurons, astrocytes, oligodendrocytes and microglia from human induced pluripotent stem cells to form neural tissue-on-chip: a neuroinflammation …

P Saglam-Metiner, E Duran, L Sabour-Takanlou… - Stem Cell Reviews and …, 2024 - Springer
Advances in stem cell (SC) technology allow the generation of cellular models that
recapitulate the histological, molecular and physiological properties of humanized in vitro …

Bioinspired microstructures through decellularization of plants for tissue engineering applications

Y Arslan, A Paradiso, N Celiktas, T Erdogan… - European Polymer …, 2023 - Elsevier
In nature, various patterns such as branches, stripes, spirals, and hexagons exist in
biological and natural systems, from nano-to macro-scale. These hierarchical structures …

Essential Oil and Supercritical Carbon Dioxide Extract of Grapefruit Peels Formulated for Candida albicans Infections: Evaluation by an in Vitro Model to Study …

B Yaldiz, P Saglam-Metiner, B Cakmak, E Kaya… - ACS …, 2022 - ACS Publications
Resistance to currently available antifungal agents raises the need to develop alternative
remedies. Candida albicans is the most common opportunistic pathogenic fungus of …

Decellularised extracellular matrix-based biomaterials for repair and regeneration of central nervous system

B Yaldiz, P Saglam-Metiner… - Expert Reviews in …, 2021 - cambridge.org
The central nervous system (CNS), consisting of the brain and spinal cord, regulates the
mind and functions of the organs. CNS diseases, leading to changes in neurological …