Neuroprotective and neurorestorative therapy represent two major drug intervention
strategies for ischemic stroke. Multiple factors such as excitotoxicity, inflammation …

Flavonoids are among the most abundant natural bioactive compounds produced by plants.
Many different activities have been reported for these secondary metabolites against …

Ischemic stroke (IS) is one of the most fatal diseases. Neuroimmunity, inflammation, and
oxidative stress play important roles in various complex mechanisms of IS. In particular, the …

Introduction A novel systemic immune-inflammation index (SII) has been proven to be
associated with outcomes in patients with cancer. Although some studies have shown that …

Background and Purpose The systemic immune-inflammation index, a new index based on
platelets, neutrophils and lymphocytes, has been shown to be associated with outcomes of …

Background Ischemic stroke, a major cause of death and disability worldwide, results from
reduced blood flow to the brain, leading to irreversible neuronal damage. Recent evidence …

Background Mitochondrial autophagy maintains mitochondrial function and cellular
homeostasis and plays a critical role in the pathological process of cerebral …

Stroke is the second most common cause of death globally and the leading cause of death
in China. The pathogenesis of cerebral ischemia injury is complex, and oxidative stress …

The gut-brain axis has been shown to play a vital role in the prognosis and recovery of
ischemic stroke (IS), which is associated with gut microbiota dysfunction and changes in the …

Cellular aging is the most severe risk factor for neurodegenerative disease. Simultaneously,
oxidative stress (OS) is a critical factor in the aging process, resulting from an imbalance …