The mammalian target of rapamycin (mTOR) senses nutrients and growth factors to
coordinate cell growth, metabolism and autophagy. Extensive research has mapped the …

LIN28 is an RNA-binding protein that is best known for its roles in promoting pluripotency via
regulation of the microRNA let-7. However, recent studies have uncovered new roles for …

Diffuse intrinsic pontine gliomas (DIPGs) are incurable childhood brainstem tumors with
frequent histone H3 K27M mutations and recurrent alterations in PDGFRA and TP53. We …

The gonad is a unique biological system for studying cell-fate decisions. However, major
questions remain regarding the identity of somatic progenitor cells and the transcriptional …

IMPs, also known as insulin-like growth factor 2 (IGF2) messenger RNA (mRNA)-binding
proteins (IGF2BPs), are highly conserved oncofetal RNA-binding proteins (RBPs) that …

During the trunk-to-tail transition, axial progenitors relocate from the epiblast to the tail bud.
Here, we show that this process entails a major regulatory switch, bringing tail bud …

HMGA (high mobility group A)(HMGA1 and HMGA2) are small non-histone proteins that can
bind DNA and modify chromatin state, thus modulating the accessibility of regulatory factors …

Liver cancer is the fatal cause of cancer deaths worldwide due to its aggressiveness and
lack of effective therapies. Tiliroside (C30H26O13) is an active compound extracted from …

The mammalian neocortex underlies our perception of sensory information, performance of
motor activities, and higher-order cognition. During mammalian embryogenesis, radial glial …

Primary sex determination is the decision by which the bipotential embryonic gonad commits
to either the testicular or ovarian fate. The developing gonad constitutes a unique paradigm …