Scleroderma renal crisis (SRC) is a rare, potentially life-threatening complication that affects
2–15% of patients with systemic sclerosis (SSc, also known as scleroderma). SRC typically …

Background: Systemic sclerosis is an immune-mediated rheumatic disease characterized by
vascular abnormalities, tissue fibrosis and autoimmune phenomena. Summary: Renal …

Testing for anti-RNA polymerase III antibodies should be incorporated into clinical care to
identify patients at high risk for SRC. Recommendations from European League Against …

Objectives To evaluate expansion of CD21 low B cells and their role in B cell homeostasis,
apoptosis, clinical manifestations and serum vascular endothelial growth factor (VEGF) in …

The spectrum of kidney involvement in systemic sclerosis (SSc) includes scleroderma renal
crisis, widely recognized as the most severe renal-vascular complication, but also several …

Among all possible systemic sclerosis internal organ complications, kidney involvement is
frequently neglected or underestimated, except for the life-threatening scleroderma renal …

Aim Endothelial dysfunction and microvascular damage are hallmarks of systemic sclerosis
(SSc). Objective of this study was to evaluate IL33 and ST2 serum levels in SSc patients and …

Abstract Background/Aims: Renal involvement is common in systemic sclerosis (SSc),
including asymptomatic reduction of glomerular filtration rate (GFR), increased renal …

Background Microvascular damage of skin and internal organs is a hallmark of systemic
sclerosis (SSc). Serum uric acid (UA) represents a marker of inflammation and endothelial …

Background The angiogenesis in systemic sclerosis (SSc) is impaired. An imbalance of pro-
angiogenic factors and angiogenesis inhibitors has been implicated in the progression of …