Monopolar spindle kinase 1 (MPS1) plays a pivotal role as a dual-specificity kinase
governing spindle assembly checkpoint activation and sister chromatid separation in …

Pyrimidine-fused derivatives that are the inextricable part of DNA and RNA play a key role in
the normal life cycle of cells. Pyrimidine-fused dinitrogenous penta-heterocycles, including …

Cdc2-like kinases (CLKs; CLK1–4) are associated with various neurodegenerative
disorders, metabolic regulation, and viral infection and have been recognized as potential …

Lung adenocarcinoma is the most frequently diagnosed subtype of nonsmall cell lung
cancer. The molecular mechanisms of the initiation and progression of lung …

Abstract A series of pyrido [2, 3-d] pyrimidin-7 (8H)-ones were designed and synthesized as
new selective orally bioavailable Threonine Tyrosine Kinase (TTK) inhibitors. One of the …

Two series of new pyridyl-bearing fused bicyclic analogues designed to target the dual-
tolerant regions of the non-nucleoside reverse transcriptase inhibitor (NNRTI)-binding …

Background Threonine and tyrosine kinase (TTK) is associated with invasion and metastasis
in various tumors. However, the prognostic importance of TTK and its correlation with …

Threonine tyrosine kinase (TTK) is a critical component of the spindle assembly checkpoint
and plays a pivotal role in mitosis. TTK has been identified as a potential therapeutic target …

Abstract Monopolar spindle 1 (MPS1) has garnered significant attention due to its pivotal
role in regulating the cell cycle. Anomalous expression and hyperactivation of MPS1 have …

A simple and efficient methodology was developed for the direct ortho C single bond H
arylation of pyrrolo [2, 3-d] pyrimidine derivatives. Aryl iodides are chosen as an arylating …