Many cellular functions are regulated by calcium (Ca2+) signals that are generated by
different signaling pathways. One of these is the inositol 1, 4, 5-trisphosphate/calcium …

Vascular tone of resistance arteries and arterioles determines peripheral vascular
resistance, contributing to the regulation of blood pressure and blood flow to, and within the …

Cardiovascular disease is a leading cause of death worldwide and accounts for> 17.3
million deaths per year, with an estimated increase in incidence to 23.6 million by 2030 …

Abstract Mitochondrial Rho (Miro) GTPases localize to the outer mitochondrial membrane
and are essential machinery for the regulated trafficking of mitochondria to defined …

Abstract Calcium (Ca 2+) plays a central role in excitation, contraction, transcription, and
proliferation of vascular smooth muscle cells (VSMs). Precise regulation of intracellular Ca …

By influencing Ca2+ homeostasis in spatially and architecturally distinct neuronal
compartments, the endoplasmic reticulum (ER) illustrates the notion that form and function …

Epigenetic modifications are emerging as major players in the pathogenesis of
neurodegenerative disorders and susceptibility to acute brain injury. DNA and histone …

Patients with heart failure (HF) have augmented vascular tone, which increases cardiac
workload, impairing ventricular output and promoting further myocardial dysfunction. The …

Essential hypertension has a high incidence worldwide, and patients with essential
hypertension endure a lifetime of medication, leading to a heavy economic burden on the …

The contractile state of resistance arteries and arterioles is a crucial determinant of blood
pressure and blood flow. Physiological regulation of arterial contractility requires constant …