Defining trained immunity and its role in health and disease
Immune memory is a defining feature of the acquired immune system, but activation of the
innate immune system can also result in enhanced responsiveness to subsequent triggers …
innate immune system can also result in enhanced responsiveness to subsequent triggers …
Targets for protection and mitigation of radiation injury
E Khodamoradi, M Hoseini-Ghahfarokhi… - Cellular and Molecular …, 2020 - Springer
Protection of normal tissues against toxic effects of ionizing radiation is a critical issue in
clinical and environmental radiobiology. Investigations in recent decades have suggested …
clinical and environmental radiobiology. Investigations in recent decades have suggested …
MYC drives platinum resistant SCLC that is overcome by the dual PI3K-HDAC inhibitor fimepinostat
J Chen, AC Guanizo, WSN Jakasekara… - Journal of Experimental …, 2023 - Springer
Background Small cell lung cancer (SCLC) is an aggressive neuroendocrine cancer with an
appalling overall survival of less than 5%(Zimmerman et al. J Thor Oncol 14: 768-83, 2019) …
appalling overall survival of less than 5%(Zimmerman et al. J Thor Oncol 14: 768-83, 2019) …
BRD4 regulates key transcription factors that drive epithelial–mesenchymal transition in castration-resistant prostate cancer
Background Androgen deprivation therapies for the hormone-dependent stages of prostate
cancer have become so effective that new forms of chemoresistant tumors are emerging in …
cancer have become so effective that new forms of chemoresistant tumors are emerging in …
Bromodomain and extra-terminal motif (BET) inhibition is synthetic lethal with loss of SMAD4 in colorectal cancer cells via restoring the loss of MYC repression
C Shi, EJ Yang, Y Liu, PK Mou, G Ren, JS Shim - Oncogene, 2021 - nature.com
The tumor suppressor SMAD4 is frequently mutated in colorectal cancer (CRC). However,
no effective targeted therapies exist for CRC with SMAD4 loss. Here, we employed a …
no effective targeted therapies exist for CRC with SMAD4 loss. Here, we employed a …
Comprehensive transcriptome profiling of BET inhibitor-treated HepG2 cells
M Baek, JC Chai, HI Choi, E Yoo, B Binas, YS Lee… - Plos one, 2022 - journals.plos.org
Hepatocellular carcinoma (HCC) is the most common primary liver cancer and poor
prognosis. Emerging evidence suggests that epigenetic alterations play a crucial role in …
prognosis. Emerging evidence suggests that epigenetic alterations play a crucial role in …
Incidence of NUT carcinoma in Western Australia from 1989 to 2014: a review of pediatric and adolescent cases from Perth Children's Hospital
T Carter, M Crook, A Murch, AH Beesley, N de Klerk… - BMC cancer, 2021 - Springer
Background NUT carcinoma (NC), previously known as NUT midline carcinoma, is a rare
and very aggressive cancer that occurs in both children and adults. NC is largely …
and very aggressive cancer that occurs in both children and adults. NC is largely …
[PDF][PDF] Targets for protection and mitigation of radiation injury
Protection of normal tissues against toxic effects of ionizing radiation is a critical issue in
clinical and environmental radiobiology. Investigations in recent decades have suggested …
clinical and environmental radiobiology. Investigations in recent decades have suggested …