Regulation of cell growth by estrogen signaling and potential targets in thyroid cancer

GG Chen, AC Vlantis, Q Zeng… - Current Cancer Drug …, 2008 - ingentaconnect.com
Thyroid cancer occurs three times more frequently in females than in males, and in females
the incidence decreases after menopause. This gender difference suggests that the growth …

Role of NF-κB in thyroid cancer

F Pacifico, A Leonardi - Molecular and cellular endocrinology, 2010 - Elsevier
Thyroid cancer is the most common neoplasia of the endocrine system and accounts for
approximately 1% of all newly diagnosed cancer cases. Its incidence has rapidly grown over …

NF-kappaB is involved in the regulation of EMT genes in breast cancer cells

BRB Pires, AL Mencalha, GM Ferreira, WF De Souza… - PloS one, 2017 - journals.plos.org
The metastatic process in breast cancer is related to the expression of the epithelial-to-
mesenchymal transition transcription factors (EMT-TFs) SNAIL, SLUG, SIP1 and TWIST1 …

Inactivation of NF-κB components by covalent binding of (−)-dehydroxymethylepoxyquinomicin to specific cysteine residues

M Yamamoto, R Horie, M Takeiri… - Journal of medicinal …, 2008 - ACS Publications
Previously, we designed and synthesized a potent NF-κB inhibitor, DHMEQ. Although
DHMEQ showed potent anti-inflammatory and anticancer activities in animals, its molecular …

BRAFV600E Promotes Invasiveness of Thyroid Cancer Cells through Nuclear Factor κB Activation

I Palona, H Namba, N Mitsutake, D Starenki… - …, 2006 - academic.oup.com
The BRAF V600E mutation is closely linked to tumorigenesis and malignant phenotype of
papillary thyroid cancer. Signaling pathways activated by BRAFV600E are still unclear …

Altered expression of c-IAP1, survivin, and Smac contributes to chemotherapy resistance in thyroid cancer cells

E Tirro, ML Consoli, M Massimino, L Manzella… - Cancer research, 2006 - AACR
Resistance to chemotherapy predicts an unfavorable outcome for patients with radioiodine-
insensitive thyroid cancer. To investigate the mechanisms underlying this resistance, we …

Immunosuppression through constitutively activated NF-κB signalling in human ovarian cancer and its reversal by an NF-κB inhibitor

H Nishio, T Yaguchi, J Sugiyama, H Sumimoto… - British journal of …, 2014 - nature.com
Background: Although T-cell immunity is thought to be involved in the prognosis of epithelial
ovarian cancer (EOC) patients, immunosuppressive conditions hamper antitumour immune …

[HTML][HTML] Melatonin suppresses thyroid cancer growth and overcomes radioresistance via inhibition of p65 phosphorylation and induction of ROS

ZW Zou, T Liu, Y Li, P Chen, X Peng, C Ma, WJ Zhang… - Redox Biology, 2018 - Elsevier
Thyroid cancer is the most common endocrine carcinoma with increasing incidence
worldwide and anaplastic subtypes are frequently associated with cancer related death …

JAK/STAT3 and NF-κB signaling pathways regulate cancer stem-cell properties in anaplastic thyroid cancer cells

K Shiraiwa, M Matsuse, Y Nakazawa, T Ogi, K Suzuki… - Thyroid, 2019 - liebertpub.com
Background: Anaplastic thyroid carcinoma (ATC) is one of the most aggressive and
refractory cancers, and a therapy with a new concept needs to be developed. Recently …

Inhibition of tumor growth by NF‐κB inhibitors

K Umezawa - Cancer science, 2006 - Wiley Online Library
NF‐κB is a transcription factor that induces inflammatory cytokines and anti‐apoptotic
proteins. NF‐κB is often constitutively activated in human cancers and leukemias, which …