Colorectal cancer (CRC) is among the most lethal and prevalent malignancies in the world
and was responsible for nearly 881,000 cancer-related deaths in 2018. Surgery and …

The function of vascular endothelial growth factor (VEGF) in cancer is not limited to
angiogenesis and vascular permeability. VEGF-mediated signalling occurs in tumour cells …

Semaphorins are membrane-bound or diffusible factors that regulate key cellular functions
and are involved in cell–cell communication. Most of the effects of semaphorins are …

Mammary tumors are the second most common neoplasia in dogs. Due to the high similarity
of canine mammary tumors (CMT) to human breast cancers (HBC), human biomarkers of …

Despite extensive research over many decades, human breast cancer remains a major
worldwide health concern. Advances in pre-clinical and clinical research has led to …

The extracellular domain of plasma membrane integrin αvβ3 contains a cell surface receptor
for thyroid hormone analogues. The receptor is largely expressed and activated in tumor …

Cell-cell communication is pivotal to guide embryo development, as well as to maintain adult
tissues homeostasis and control immune response. Among extracellular factors responsible …

Epithelial tissues robustly respond to internal and external stressors via dynamic cellular
rearrangements. Cell extrusion acts as a key regulator of epithelial homeostasis by …

Plexin transmembrane receptors and their semaphorin ligands, as well as their co-receptors
(Neuropilin, Integrin, VEGFR2, ErbB2, and Met kinase) are emerging as key regulatory …

The rise and fall of estrogen and progesterone across menstrual cycles and during
pregnancy regulates breast development and modifies cancer risk. How these hormones …