Loss or rearrangement of genetic information can result from incorrect responses to DNA
double strand breaks (DSBs). The cellular responses to DSBs encompass a range of highly …

Condensates are biomolecular assemblies that concentrate biomolecules without the help
of membranes. They are morphologically highly versatile and may emerge via distinct …

We show for the first time that natural 2, 5-diketopiperazines (cyclic dipeptides) can suppress
the activity of the important anticancer target poly (ADP-ribose) polymerase (PARP). Cyclo (L …

Apart from its vital function as a redox cofactor, nicotinamide adenine dinucleotide (NAD+)
has emerged as a crucial substrate for NAD+‐consuming enzymes, including poly (ADP …

Biomolecular condensates are nonmembrane cellular compartments whose formation in
many cases involves phase separation (PS). Despite much research interest in this …

Our understanding of how, and the extent to which, phytopathogens reconfigure host
metabolic pathways to enhance virulence is remarkably limited. Here we investigate the …

Adenosine diphosphate-ribose (ADP-ribose) and its derivatives play important roles in a
series of complex physiological procedures. The design and synthesis of artificial ADP …

Abstract Poly (ADP-ribose) polymerase (PARP) enzyme catalyzes the transfer of ADP-ribose
into target proteins. Therefore, PARP is responsible for DNA repair, cell proliferation, and …

Abstract Poly (ADP-ribosylation)(PARylation) by poly (ADP-ribose) polymerases (PARPs) is
a highly regulated process that consists of the covalent addition of polymers of ADP-ribose …

Inhibition of DNA repair enzymes tyrosyl-DNA phosphodiesterase 1 and poly (ADP-ribose)
polymerases 1 and 2 in the presence of pyrimidine nucleoside derivatives was studied here …