An essential step in the life cycle of malaria parasites is their egress from hepatocytes, which
enables the transition from the asymptomatic liver stage to the pathogenic blood stage of …

Apicomplexa encompasses a large number of intracellular parasites infecting a wide range
of animals. Cyclic nucleotide signaling is crucial for a variety of apicomplexan life stages and …

Apicomplexan parasites use Ca 2+-regulated exocytosis to secrete essential virulence
factors from specialized organelles called micronemes. Ca 2+-dependent protein kinases …

In apicomplexan parasites, the transition between replication and dissemination is regulated
by fluctuations in cytosolic calcium concentrations, transduced in part by calcium-dependent …

The versatility of cellular response arises from the communication, or crosstalk, of signaling
pathways in a complex network of signaling and transcriptional regulatory interactions …

Phosphoinositides are a biologically essential class of phospholipids that contribute to
organelle membrane identity, modulate membrane trafficking pathways, and are central …

Toxoplasma gondii, a protozoan parasite with the ability to infect various warm-blooded
vertebrates, including humans, is the causative agent of toxoplasmosis. This infection poses …

The protozoan parasite Cryptosporidium is a leading cause of diarrhea in young children.
The parasite's life cycle involves a coordinated and timely progression from asexual to …

Apicomplexan parasites balance proliferation, persistence, and spread in their metazoan
hosts. AGC kinases, such as PKG, PKA, and the PDK1 ortholog SPARK, integrate …

Apicomplexa is a phylum of protist parasites, notable for causing life-threatening diseases
including malaria, toxoplasmosis, cryptosporidiosis, and babesiosis. Apicomplexan …