Sarcomas are heterogeneous and clinically challenging soft tissue and bone cancers.
Although constituting only 1% of all human malignancies, sarcomas represent the second …

Ewing sarcoma, a highly aggressive bone and soft-tissue cancer, is considered a prime
example of the paradigms of a translocation-positive sarcoma: a genetically rather simple …

Cancer is a complex disease in which both genetic defects and microenvironmental
components contribute to the development, progression, and metastasization of disease …

Tumor vasculature creates a hostile tumor microenvironment (TME) in vivo and nourishes
cancers, resulting in cancer progression and drug resistance. To mimic the biochemical and …

Hierarchically structured polymer fibers encompassing 1-D, 2-D, and 3-D structures with at
least one dimension nano-to micro-meters in size have recently received an increasing …

Electrospinning forms fibers from either an electrically charged polymer solution or polymer
melt. Over the past decades, it has become a simple and versatile method for nanofiber …

For decades, scientists have been using two-dimensional cell culture platforms for high-
throughput drug screening of anticancer drugs. Growing evidence indicates that the results …

Undifferentiated small round cell sarcomas (SRCSs) of bone and soft tissue comprise a
heterogeneous group of highly aggressive tumours associated with a poor prognosis …

This article reviews the recent progress of electrospun nanofibers in cancer research. It
begins with a brief introduction to the emerging potential of electrospun nanofibers in cancer …

Numerous studies to date have contributed to a paradigm shift in modeling cancer, moving
from the traditional two-dimensional culture system to three-dimensional (3D) culture …