Electrical signaling in neurons is based on the operation of plasmalemmal ion pumps and
carriers that establish transmembrane ion gradients, and on the operation of ion channels …

Electroneutral cation-Cl− cotransporters compose a family of solute carriers in which cation
(Na+ or K+) movement through the plasma membrane is always accompanied by Cl− in a 1 …

Abstract The K+-Cl− cotransporter KCC2 is responsible for maintaining low Cl−
concentration in neurons of the central nervous system (CNS), which is essential for …

Cells respond to stress stimuli by mounting specific responses. During osmotic and oxidative
stress, cation chloride cotransporters, eg Na-K-2Cl and K-Cl cotransporters, are activated to …

Maintenance of extracellular K+ concentration within a narrow range is vital for numerous
cell functions, particularly electrical excitability of heart and muscle. Potassium homeostasis …

GABAergic signalling has the unique property of 'ionic plasticity', which is based on short‐
term and long‐term changes in the Cl− and HCO3− ion concentrations in the postsynaptic …

▪ Abstract The Na-K-Cl cotransporters are a class of ion transport proteins that transport Na,
K, and Cl ions into and out of cells in an electrically neutral manner, in most cases with a …

In recent years, it has become evident that the volume of a given cell is an important factor
not only in defining its intracellular osmolality and its shape, but also in defining other …

The electroneutral cation-chloride-coupled cotransporter gene family (SLC12) was identified
initially at the molecular level in fish and then in mammals. This nine-member gene family …

Peripheral neuropathy associated with agenesis of the corpus callosum (ACCPN) is a
severe sensorimotor neuropathy associated with mental retardation, dysmorphic features …