The mammary gland has a remarkable capacity for regulation at a local level, particularly
with respect to its main function: milk secretion. Regulation of milk synthesis has significant …

Calcium homeostasis is crucial for the normal function of the organism. Parathyroid
hormone, calcitriol and calcitonin play critical roles in the homeostatic regulation of calcium …

Breast cells drive bone demineralization during lactation and metastatic cancers. A shared
mechanism among these physiological and pathological states is endocrine secretion of …

Hypocalcemia in dairy cows is caused by the sudden increase in calcium demand by the
mammary gland for milk production at the onset of lactation. Serotonin (5-HT) is a key factor …

ABSTRACT The monoamine serotonin (5-hydroxytryptamine, 5-HT) has been reported to
inhibit milk protein gene expression and increase mammary epithelial cell (MEC) tight …

In the present study, the analysis of epithelial cells derived from various sources was
undertaken, beginning from the mammary gland tissue through the primary cultures and …

Lactation is characterized by massive transcellular flux of calcium, from the basolateral side
of the mammary alveolar epithelium (blood) into the ductal lumen (milk). Regulation of …

The dry period is required to facilitate cell turnover in the bovine mammary gland in order to
optimize milk yield in the next lactation. Traditionally, an 8-week dry period has been a …

Serotonin (5-HT), a neurotransmitter produced in mammary epithelial cells (MECs), acts via
autocrine–paracrine mechanisms on MECs to regulate milk secretion in a variety of species …

Serotonin plays a diverse role in maternal and mammary metabolism. Recent research in
the dairy cow has shown a relationship between serotonin and calcium, with increased …