Interleukin-2 was discovered in 1976 as a T-cell growth factor. It was the first type I cytokine
cloned and the first for which a receptor component was cloned. Its importance includes its …

The human immunodeficiency virus type I (HIV-1) has developed several strategies to
condition the host environment to promote viral replication and spread. Viral proteins have …

Cellular senescence is a stable cell cycle arrest that limits the proliferation of pre-cancerous
cells. Here we demonstrate that scaffold-attachment-factor A (SAFA) and the long noncoding …

Mechanisms of tissue-specific gene expression regulation via 3D genome organization are
poorly understood. Here we uncover the regulatory chromatin network of developing T cells …

The function of the subnuclear structure the promyelocytic leukaemia (PML) body is unclear
largely because of the functional heterogeneity of its constituents. Here, we provide the …

In vertebrates, the conserved Wnt signalling cascade promotes the stabilization and nuclear
accumulation of β-catenin, which then associates with the lymphoid enhancer factor/T cell …

The packaging of newly replicated and repaired DNA into chromatin is crucial for the
maintenance of genomic integrity. Acetylation of histone H3 core domain lysine 56 …

SATB1 regulates gene expression by acting as a" docking site" for several chromatin
remodeling enzymes and also by recruiting corepressors (HDACs) or coactivators (HATs) …

Compartmentalized distribution of functional components is a hallmark of the eukaryotic
nucleus. Technological advances in recent years have provided unprecedented insights into …

Cellular senescence and apoptosis have evolved to restrain unwarranted proliferation of
potentially tumorigenic cells. Here we show that overexpression of the E3 SUMO ligase …