Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …

The Global Burden of Disease Study identified cardiovascular risk factors as leading causes
of global deaths and life years lost. Endothelial dysfunction represents a pathomechanism …

Environmental pollution and non-chemical stressors such as mental stress or traffic noise
exposure are increasingly accepted as health risk factors with substantial contribution to …

In kidney disease (KD), several factors released into the bloodstream can induce a series of
changes in the heart, leading to a wide variety of clinical situations called cardiorenal …

O-linked attachment of the monosaccharide β-N-acetyl-glucosamine (O-GlcNAcylation) is a
post-translational modification occurring on serine and threonine residues, which is evolving …

Background/Aims: To evaluate the effects of the antioxidant N-acetylcysteine (NAC) on
cardiac structure and function in rats with long-term ascending aortic stenosis (AS). Methods …

Background Cardiovascular diseases (CVD) account for approximately 50% of the total
deaths in Turkey. Most of them are related with atherosclerotic coronary heart disease …

Chronic ventricular pressure overload (PO) results in congestive heart failure (CHF) in which
myocardial fibrosis develops in concert with ventricular dysfunction. Caveolin-1 is important …

Endothelium-dependent hyperpolarization (EDH) factor is one of endothelium-derived
relaxing factors and plays important roles especially in microvessels. We have previously …

Transplant vasculopathy (TV) represents a major obstacle to long-term graft survival and
correlates with severity of ischemia reperfusion injury (IRI). Donor administration of the nitric …