Despite extensive research, current glioma therapies are still unsatisfactory, and novel
approaches are pressingly needed. In recent years, both nonreplicative viral vectors and …

Glioblastoma is the most common and aggressive adult brain tumour. Over the last 10 years
it has emerged that the subventricular zone (SVZ), the largest adult neural stem cell niche …

Gliomas, the most malignant form of brain tumors, contain a small subpopulation of glioma
stem cells (GSCs) that are implicated in therapeutic resistance and tumor recurrence …

Elevated expression of the DNA damage response proteins PARP1 and poly (ADP-ribose)
glycohydrolase (PARG) in glioma stem cells (GSCs) suggests that glioma may be a unique …

Recent research has focused on the hypothesis that the growth and regeneration of
glioblastoma (GB) is sustained by a subpopulation of self-renewing stem-like cells. This has …

Glioblastoma stem cells (GBM-SCs) are believed to be a subpopulation within all
glioblastoma (GBM) cells that are in large part responsible for tumor growth and the high …

Invasive grade III and IV malignant gliomas remain difficult to treat with a typical survival time
post-diagnosis hovering around 16 months with only minor extension thereof seen in the …

Glioblastoma multiforme (GBM), a WHO grade IV diffuse glioma, is a highly aggressive brain
tumor with a median survival of less than a year. Characterized by robust proliferation and …

Surgical access to subcortical lesions in the sensorimotor area can lead to a high degree of
cognitive and functional morbidity through injury to white matter fiber tracts. Inherent …

Glioblastoma (GBM) is the most prevalent and most malignant (WHO grade IV) type of brain
tumor in adults [1, 2]. In the United States, there are~ 10,000 new cases diagnosed annually …