The Dishevelled gene was first identified in Drosophila mutants with disoriented hair and
bristle polarity [[1],[2],[3]]. The Dsh gene (Dsh/Dvl, in Drosophila and vertebrates …

Dopaminergic (DA) neurons of the ventral midbrain (VM) play vital roles in the regulation of
voluntary movement, emotion and reward. They are divided into the A8, A9 and A10 …

Idiopathic Parkinson's disease is characterized by a progressive loss of dopaminergic
neurons, but the exact disease aetiology remains largely unknown. To date, Parkinson's …

Small guanosine triphosphatases (GTPases) of the Ras superfamily are key regulators of
many key cellular events such as proliferation, differentiation, cell cycle regulation …

Wnts are a highly conserved family of lipid-modified glycoproteins that work as morphogens
to activate several signaling pathways, leading to remodeling of the cytoskeleton and the …

Stem cell technologies provide new opportunities for modeling cells in health and disease
and for regenerative medicine. In both cases, developmental knowledge and defining the …

Abstract Post-synaptic density-95, disks-large and zonula occludens-1 (PDZ) domains are
small globular protein–protein interaction domains widely conserved from yeast to humans …

The search for new therapeutical targets for cutaneous melanoma and other cancers is an
ongoing task. We expanded this knowledge by evaluating whether opsins, light-and thermo …

Parkinson's disease (PD) is a chronic and progressive neurodegenerative disease leading
to motor dysfunction and, in some cases, dementia. Transcriptome analysis is one promising …

Parkinson's disease (PD) is a neurodegenerative movement disorder characterized with
dopaminergic neuron (DaN) loss within the substantia nigra (SN). Despite bulk studies …