Remarkable diversity in the domain of genome loci architecture, structure of effector
complex, array of protein composition, mechanisms of adaptation along with difference in …

Introduction Immunotherapies for multiple sclerosis (MS) significantly decrease the risk of
new relapses. However, the chronic compartmentalized inflammation and …

Objective Preterm brain injury is a major cause of disability in later life, and may result in
motor, cognitive and behavioural impairment for which no treatment is currently available …

Background Activated microglia-mediated neuroinflammation has been regarded as an
underlying key player in the pathogenesis of subarachnoid hemorrhage (SAH)-induced …

Multiple lines of evidence suggest that disease-related neurodegeneration seems to be a
multifactorial process that involves different cytotoxic pathways converging in cell death …

Extracellular exosomes are formed inside the cytoplasm of cells in compartments known as
multivesicular bodies. Thus, exosomes contain cytoplasmic content. Multivesicular bodies …

Human genetics research employs the two opposing approaches of forward and reverse
genetics. While forward genetics identifies and links a mutation to an observed disease …

Oligodendrocytes play a crucial role in our central nervous system (CNS) by myelinating
axons for faster action potential conduction, protecting axons from degeneration, structuring …

Introduction: Multiple sclerosis (MS) is a chronic inflammatory condition of the central
nervous system with heterogeneous features. Primary progressive (PP) MS is a rare disease …

“Stem cell tourism” is a rising Internet-based industry that aims to offer unproven procedures
to patients with incurable diseases. This unregulated activity is reaching the neurologist's …