Increasing evidence suggests that Alzheimer's disease pathogenesis is not restricted to the
neuronal compartment, but includes strong interactions with immunological mechanisms in …

Neuroinflammation is an inflammatory response in the brain and spinal cord, which can
involve the activation of microglia and astrocytes. It is a common feature of many central …

While emerging evidence suggests that neuroinflammation plays a crucial role in
Alzheimer's disease, the impact of the microglia response in Alzheimer's disease remains a …

The 18 kDa translocator protein (TSPO), previously known as the peripheral
benzodiazepine receptor, is predominately localized to the outer mitochondrial membrane in …

Schizophrenia is a debilitating disorder that typically begins in adolescence and is
characterized by perceptual abnormalities, delusions, cognitive and behavioural …

Astrocytes and microglia become reactive under most brain pathological conditions, making
this neuroinflammation process a surrogate marker of neuronal dysfunction …

Since the original identification of microglia as a principal player in the brain's innate
immune response, microglial activation has been widely studied. Recent studies suggest …

It is evident that once psychosis is present in patients with schizophrenia, the underlying
biological process of the illness has already been ongoing for many years. At the time of …

Positron emission tomography (PET) imaging with radiotracers that target translocator
protein 18 kDa (TSPO) has become a popular approach to assess putative …

Glial activation participates in the mediation of pain including neuropathic pain, due to
release of neuroexcitatory, proinflammatory products. Glial activation is now known to occur …