Background Tumors are highly plastic metabolic entities composed of cancer and host cells
that can adopt different metabolic phenotypes. For energy production, cancer cells may use …

Monocarboxylate transporters (MCTs) constitute a family of 14 members among which
MCT1–4 facilitate the passive transport of monocarboxylates such as lactate, pyruvate and …

Elevated production of collagen-rich extracellular matrix is a hallmark of cancer-associated
fibroblasts (CAFs) and a central driver of cancer aggressiveness. Here we find that proline, a …

Maintenance of both normal epithelial tissues and their malignant counterparts is supported
by the host tissue stroma. The tumor stroma mainly consists of the basement membrane …

Cell motility is central to tissue homeostasis in health and disease, and there is hardly any
cell in the body that is not motile at a given point in its life cycle. Important physiological …

Monocarboxylate transporters (MCTs) belong to the SLC16 gene family, presently
composed by 14 members. MCT1-MCT4 are proton symporters, which mediate the …

The induction of hypoxia-inducible factor 1 (HIF-1) activity, either as a result of intratumoral
hypoxia or loss-of-function mutations in the VHL gene, leads to a dramatic reprogramming of …

Tumor metabolism consists of complex interactions between oxygenation states,
metabolites, ions, the vascular network and signaling cascades. Accumulation of lactate …

High lactate generation and low glucose oxidation, despite normal oxygen conditions, are
commonly seen in cancer cells and tumors. Historically known as the Warburg effect, this …

Background Gliomas exhibit high glycolytic rates, and monocarboxylate transporters (MCTs)
play a major role in the maintenance of the glycolytic metabolism through the proton-linked …