[HTML][HTML] Monocarboxylate transporters in cancer
VL Payen, E Mina, VF Van Hée, PE Porporato… - Molecular …, 2020 - Elsevier
Background Tumors are highly plastic metabolic entities composed of cancer and host cells
that can adopt different metabolic phenotypes. For energy production, cancer cells may use …
that can adopt different metabolic phenotypes. For energy production, cancer cells may use …
[HTML][HTML] Monocarboxylate transporters in the brain and in cancer
J Pérez-Escuredo, VF Van Hée, M Sboarina… - … et Biophysica Acta (BBA …, 2016 - Elsevier
Monocarboxylate transporters (MCTs) constitute a family of 14 members among which
MCT1–4 facilitate the passive transport of monocarboxylates such as lactate, pyruvate and …
MCT1–4 facilitate the passive transport of monocarboxylates such as lactate, pyruvate and …
[HTML][HTML] Cancer-associated fibroblasts require proline synthesis by PYCR1 for the deposition of pro-tumorigenic extracellular matrix
EJ Kay, K Paterson, C Riera-Domingo, D Sumpton… - Nature …, 2022 - nature.com
Elevated production of collagen-rich extracellular matrix is a hallmark of cancer-associated
fibroblasts (CAFs) and a central driver of cancer aggressiveness. Here we find that proline, a …
fibroblasts (CAFs) and a central driver of cancer aggressiveness. Here we find that proline, a …
[HTML][HTML] The role of tumor stroma in cancer progression and prognosis: emphasis on carcinoma-associated fibroblasts and non-small cell lung cancer
RM Bremnes, T Dønnem, S Al-Saad, K Al-Shibli… - Journal of thoracic …, 2011 - Elsevier
Maintenance of both normal epithelial tissues and their malignant counterparts is supported
by the host tissue stroma. The tumor stroma mainly consists of the basement membrane …
by the host tissue stroma. The tumor stroma mainly consists of the basement membrane …
Role of ion channels and transporters in cell migration
A Schwab, A Fabian, PJ Hanley… - Physiological …, 2012 - journals.physiology.org
Cell motility is central to tissue homeostasis in health and disease, and there is hardly any
cell in the body that is not motile at a given point in its life cycle. Important physiological …
cell in the body that is not motile at a given point in its life cycle. Important physiological …
Role of monocarboxylate transporters in human cancers: state of the art
C Pinheiro, A Longatto-Filho, J Azevedo-Silva… - Journal of bioenergetics …, 2012 - Springer
Monocarboxylate transporters (MCTs) belong to the SLC16 gene family, presently
composed by 14 members. MCT1-MCT4 are proton symporters, which mediate the …
composed by 14 members. MCT1-MCT4 are proton symporters, which mediate the …
Regulation of cancer cell metabolism by hypoxia-inducible factor 1
GL Semenza - Seminars in cancer biology, 2009 - Elsevier
The induction of hypoxia-inducible factor 1 (HIF-1) activity, either as a result of intratumoral
hypoxia or loss-of-function mutations in the VHL gene, leads to a dramatic reprogramming of …
hypoxia or loss-of-function mutations in the VHL gene, leads to a dramatic reprogramming of …
Tumor metabolism of lactate: the influence and therapeutic potential for MCT and CD147 regulation
KM Kennedy, MW Dewhirst - Future Oncology, 2010 - Taylor & Francis
Tumor metabolism consists of complex interactions between oxygenation states,
metabolites, ions, the vascular network and signaling cascades. Accumulation of lactate …
metabolites, ions, the vascular network and signaling cascades. Accumulation of lactate …
[HTML][HTML] Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells
T McFate, A Mohyeldin, H Lu, J Thakar… - Journal of Biological …, 2008 - ASBMB
High lactate generation and low glucose oxidation, despite normal oxygen conditions, are
commonly seen in cancer cells and tumors. Historically known as the Warburg effect, this …
commonly seen in cancer cells and tumors. Historically known as the Warburg effect, this …
Monocarboxylate transporters (MCTs) in gliomas: expression and exploitation as therapeutic targets
V Miranda-Goncalves, M Honavar, C Pinheiro… - Neuro …, 2013 - academic.oup.com
Background Gliomas exhibit high glycolytic rates, and monocarboxylate transporters (MCTs)
play a major role in the maintenance of the glycolytic metabolism through the proton-linked …
play a major role in the maintenance of the glycolytic metabolism through the proton-linked …