Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

Graph neural networks (GNNs) have been widely used in molecular property prediction, but
explaining their black-box predictions is still a challenge. Most existing explanation methods …

Rationale l-Glutamate is the major excitatory neurotransmitter in the central nervous system
(CNS) and mediates its actions via activation of both ionotropic and metabotropic receptor …

In recent years, withdrawal of marketed drugs including sertindole, grepafloxacin, and
terfenadine owing to prolongation of the length of time between the start of the Q wave and …

hERG-mediated sudden death as a side effect of non-antiarrhythmic drugs has been
receiving increased regulatory attention. Perhaps owing to the unique shape of the ligand …

Abstract l-glutamate is an excitatory neurotransmitter in the central nervous system (CNS),
which can activate ionotropic receptors (iGluRs) and metabotropic (mGluRs) receptors. N …

The extracellular amino-terminal domains (ATDs) of the ionotropic glutamate receptor
subunits form a semiautonomous component of all glutamate receptors that resides distal to …

The lack of effective therapies for epileptic patients and the potentially harmful
consequences of untreated seizure incidents have made epileptic disorders in humans a …

The discovery of NMDA receptors (NMDARs) was made possible by the synthesis and study
of NMDA (Figure 12.1) and various NMDAR antagonists by Jeff Watkins and colleagues [1] …