Due to the complexity of multifactorial diseases, single-target drugs do not always exhibit
satisfactory efficacy. Recently, increasing evidence indicates that simultaneous modulation …

The development of multitarget-directed ligands (MTDLs) has become a widely focused
research topic, but rational design remains as an enormous challenge. This paper reviews …

Multitargeting compounds comprising activity on more than a single biological target have
gained remarkable relevance in drug discovery owing to the complexity of multifactorial …

Polypharmacology is a concept where a molecule can interact with two or more targets
simultaneously. It offers many advantages as compared to the conventional single-targeting …

1, 2, 4-triazole is an important nucleus present in a large number of compounds. More than
thirty-five compounds containing this nucleus are introduced into the market. 1, 2, 4-triazole …

The dominant paradigm in drug discovery is to design ligands with maximum selectivity to
act on individual drug targets. With the target-based approach, many new chemical entities …

Many enzymes catalyse reactions that have an oestrogen as a substrate and/or a product.
The reactions catalysed include aromatisation, oxidation, reduction, sulfonation …

The phytochemical resveratrol has been shown to exert numerous health benefits in
preclinical studies, but its rapid metabolism and resulting poor bioavailability may limit …

Quinazolinone-based anticancer agents were designed, decorated with functional groups
from a 2-methoxyestradiol-based microtubule disruptor series, incorporating the aryl …

Steroid sulphatase (STS), involved in the hydrolysis of steroid sulphates, plays an important
role in the formation of both active oestrogens and androgens. Since these steroids …