Depression is common, costly, debilitating, and associated with increased risk of suicide. It is
one of the leading global public health problems. Although existing available …

The mystical experience is a potential psychological mechanism to influence outcome in
psychedelic therapy. It includes features such as oceanic boundlessness, ego dissolution …

Background: Preliminary data suggest that psilocybin-assisted treatment produces
substantial and rapid antidepressant effects in patients with major depressive disorder …

Importance Psilocybin shows promise as a treatment for major depressive disorder (MDD).
Objective To evaluate the magnitude, timing, and durability of antidepressant effects and …

Background Psilocybin has been suggested as a novel, rapid-acting treatment for
depression. Two consecutive doses have been shown to markedly decrease symptom …

Background Psilocybin may have antidepressant properties, but direct comparisons
between psilocybin and established treatments for depression are lacking. Methods In a …

Psychedelic drugs including psilocybin, N, N ʹ-dimethyltryptamine (DMT) and lysergic acid
diethylamide (LSD) are undergoing a renaissance as potentially useful drugs for various …

Drugs that target the human serotonin 2A receptor (5-HT2AR) are used to treat
neuropsychiatric diseases; however, many have hallucinogenic effects, hampering their use …

Classic psychedelics, such as LSD, psilocybin, and the DMT-containing beverage
ayahuasca, show some potential to treat depression, anxiety, and addiction. Importantly …

Renewed interest in the use of psychedelics in the treatment of psychiatric disorders
warrants a better understanding of the neurobiological mechanisms underlying the effects of …